1st Edition

Chromatographic Techniques in the Forensic Analysis of Designer Drugs

ISBN 9781138033283
Published February 6, 2018 by CRC Press
478 Pages

USD $219.95

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Book Description

There is a dramatic rise of novel drug use due to the increased popularity of so-called designer drugs. These synthetic drugs can be illegal in some countries, but legal in others and novel compounds unknown to drug chemistry emerge monthly. This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials. The methods are based on molecular characteristics of the drugs belonging to each individual class of compounds, so it will be clear how the current methods are adaptable to future new drugs that appear in the market.

Table of Contents

Preface   xiii

About the Editors  xv

Contributors  xix

Section I

Chapter 1 Introduction  3

Teresa Kowalska, Mieczysław Sajewicz, and Joseph Sherma

Chapter 2 Designer Drugs: Legislating for Tomorrow Through the Use

of Class Definitions and Pharmacophore Principles  17

Gregory W. Endres, Travis J. Worst, and Jon E. Sprague

Chapter 3 Alternative Legislation with Designer Drugs  29

Dariusz Zuba

Chapter 4 Biological Background of Designer Drugs  39

Łukasz Komsta and Katarzyna Wicha-Komsta

Chapter 5 Liquid Chromatography–Mass Spectrometry in the Analysis

of Designer Drugs  67

Beril Anilanmert

Chapter 6 Ambient Plasma Ionization Techniques in Forensic Analysis  115

Przemysław Mielczarek and Marek Smoluch

Chapter 7 Application of LC-QTOFMS for the Identification

of the Structure of New Psychoactive Substances  123

Karolina Sekuła and Dariusz Zuba

Chapter 8 Rapid Generation of Metabolites by Electrochemical Method 147

Przemysław Mielczarek and Marek Smoluch

Chapter 9 Gas Chromatography–Mass Spectrometry in the Analysis

of Designer Drugs   157

Bogumiła Byrska and Roman Stanaszek

Chapter 10 NMR Spectroscopy in the Analysis of Illegal Drugs  177

Vlatka Vajs, Iris Djordjević, Ljubodrag Vujisić,

and Slobodan M. Milosavljević

Chapter 11 Preparation of Biological Material for Toxicological Analysis   199

Milena Majchrzak and Rafał Celiński

Chapter 12 Discrimination among Designer Drug Isomers

by Chromatographic and Spectrometric Methods   211

Piotr Adamowicz and Dariusz Zuba

Section II

Chapter 13 Mass Spectrometric Analysis Applied for the Determination

of Synthetic Cannabinoids   235

Akira Namera, Takeshi Saito, and Yuji Fujita

Chapter 14 Cathinone Derivatives and Their Analysis  251

Milena Majchrzak and Rafał Celiński

Chapter 15 2C Derivatives of Phenylethylamines and Their Analysis   277

Beril Anilanmert, Fatma Cavuş Yonar, and Ali Acar Özdemir

Chapter 16 NBOMe Derivatives of Phenylethylamines and Their Analysis  305

Beril Anilanmert, Fatma Cavuş Yonar, and Sena Cağlar Andaç

Chapter 17 Forensic Analysis of Piperazines  329

Chipo Kuleya and Michael D. Cole

Chapter 18 Chromatographic Analysis of Fentanyl and Its Analogs  341

Thomas A. Brettell and Matthew R. Wood

Chapter 19 Modern Techniques for the Identification of Tryptamines 369

Dariusz Zuba

Chapter 20 Toxicological Analysis of New Opioids  391

Karina Sommerfeld-Klatta, Artur Teżyk, and Bogna Geppert

Chapter 21 Toxicological Analysis of Designer Benzodiazepines  419

Artur Teżyk, Karina Sommerfeld-Klatta, and Bogna Geppert

Chapter 22 Thin-Layer Chromatography in the Analysis of Designer Drugs  439

Joseph Sherma, Teresa Kowalska, and Mieczysław Sajewicz

Index  457

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Teresa Kowalska earned an MSc in chemistry from the former Pedagogical High School in Katowice, Poland, a PhD in physical chemistry from the University of Silesia, Katowice, and a DSc in physical chemistry from The Maria Curie-Sklodowska University in Lublin, Poland. She has authored and coauthored approximately 300 original research and review papers, 16 invited book chapters, and approximately 500 conference papers for scientific conferences. She is also coeditor-in-chief of the international chromatography journal Acta Chromatographica and an editorial board member for several chromatography journals. Her main research interests focus on applications of thin-layer, high-performance liquid and gas chromatography to physicochemical problems.

Mieczyslaw Sajewicz earned an MSc and a PhD in chemistry from the University of Silesia, Katowice, Poland, and a DSc in pharmacy from Collegium Medicum, Jagiellonian University, Kraków, Poland. He has authored and coauthored over 150 original research papers, over 350 conference papers, an encyclopedia entry in Encyclopedia of Chromatography, Second Edition, and two book chapters. He is an editorial board member and coeditor-in-chief of Acta Chromatographica and an editorial board member for the analytical chemistry section of The Scientific World Journal. He is also a member of the Organizing Committee of the annual all-Polish Symposium on Chromatographic Methods of Investigating the Organic Compounds and co-chairman of the Scientific and Organizing Committee of the same event.

Joseph Sherma is professor emeritus of chemistry at Lafayette College, Easton, Pennsylvania. He earned his PhD in analytical chemistry from Rutgers, the State University, New Brunswick, New Jersey, under the supervision of the renowned ion exchange chromatography expert William Rieman III. He taught courses in analytical chemistry for more than 40 years, was head of the Lafayette College Chemistry Department for 12 years, and continues to supervise research students. He has authored, coauthored, edited, or coedited more than 750 publications, including research papers and review articles; approximately 30 invited book chapters; and more than 65 books and U.S. government agency manuals in the areas of analytical chemistry and chromatography. He served for 23 years as editor for residues and trace elements of the Journal of AOAC International and is currently its acquisitions editor. He received the 1995 ACS Award for Research at an Undergraduate Institution sponsored by Research Corporation, and the first 2009 issue of the journal Acta Universitatis Cibiensis, Seria F, Chemia was dedicated in honor of his teaching, research, and publication accomplishments in analytical chemistry and chromatography.