Chronic Inflammation : Molecular Pathophysiology, Nutritional and Therapeutic Interventions book cover
1st Edition

Chronic Inflammation
Molecular Pathophysiology, Nutritional and Therapeutic Interventions

ISBN 9781439872116
Published September 17, 2012 by CRC Press
472 Pages 11 Color & 63 B/W Illustrations

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Book Description

Although acute inflammation is a healthy physiological response indicative of wound healing, chronic inflammation has been directly implicated in a wide range of degenerative human health disorders encompassing almost all present day non-communicable diseases including autoimmune diseases, obesity, diabetes and atherosclerosis. Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions provides an exposition of the process of chronic inflammation in three parts:

  1. Systems Biology of Inflammation and Regulatory Mechanisms describes the process of chronic inflammation including initiation, progression, and resolution.
  2. Pathologies Associated with Inflammation gives a rigorous and critical treatment of specific human health disorders where chronic inflammation plays a major role.
  3. Nutrition & Therapeutics for Inflammatory Diseases details the protective abilities of structurally diverse antioxidants, phytochemicals, anti-inflammatory diets, omega-3 fatty acids, NSAIDs, disease modifying anti-rheumatic drugs, and novel regimens.

Designed for scientists as well as clinicians, Chronic Inflammation provides critical understanding of the key checkpoints that regulate chronic inflammation. Going beyond the epidemiology of chronic inflammation, the text covers regulatory mechanisms controlling inflammation initiation, progression, and resolution. The authors address pathologies associated with inflammation and provide various nutritional and therapeutic interventions for inflammatory diseases.

Table of Contents

Systems Biology of Inflammation and Regulatory Mechanisms: At the Interface between Acute and Chronic Inflammation: Insights from Computational Modeling. The Cellular Component of Chronic Inflammation. Mast Cells in Chronic Inflammation. Hypoxia and Hypoxia-Inducible Factor in Inflammation. Bioactive Phospholipid Mediators of Inflammation. Hematopoietic Stem Cells in Atherosclerotic Development and Resolution. Inflammation as a Confounding Factor in Regenerative Medicine. NOX in the CNS: Inflammation and Beyond. Resolution of Inflammation. H2S in Inflammation.
Pathologies Associated with Inflammation: Is There a Connection between Inflammation and Oxidative Stress? Chronic Inflammation and Cancer: A Matter of Lifestyle. Chronic Wounds and Inflammation. Multiphasic Roles for TGF-Beta in Scarring: Implications for Therapeutic Intervention. Natural Vitamin E Tocotrienol against Neuroinflammation and Oxidative Stress. Inflammatory Cascades in Autoimmune Disease. Shear Stress and Vascular Inflammation: A Study in the Lung. NGF and Its Receptor System in Inflammatory Diseases.
Nutrition & Therapeutics for Inflammatory Diseases: Inflammation, Oxidative Stress, and Antioxidants. Lipid Biomarkers of Inflammation. Physical Activity and Inflammation: An Overview. Omega-6 and Omega-3 Polyunsaturated Fatty Acids and Inflammatory Processes. Anti-Inflammatory Phytochemicals, Obesity, and Diabetes: An Overview. Anti-Inflammatory Nutraceuticals and Herbal Medicines for the Management of Metabolic Syndrome. Epigenetics and Nutriepigenomics in Chronic Inflammatory Lung Diseases: Nutritional and Therapeutic Interventions. Biologics: Molecular Medicine from Bench to Bedside. Disease Modifying Anti-Rheumatic Drugs. Nonsteroidal Anti-Inflammatory Drugs.

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Sashwati Roy, PhD, is an Associate Professor in the Department of Surgery and Director, Laser Capture Molecular Core in the College of Medicine, Ohio State University, Columbus.

Debasis Bagchi, PhD, is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at University of Houston, Texas. His research interests include free radicals, human diseases, carcinogenesis, pathophysiology, mechanistic aspects of cytoprotection by antioxidants, regulatory pathways in obesity, and gene expression.

Siba P. Raychaudhuri, MD, is the Chief of the Rheumatology Division at the VA Medical Center in Sacramento, California, and a Clinical Assistant Professor in the Division of Rheumatology, Allergy and Clinical Immunology at the University of California, Davis. Dr. Raychaudhuri’s major research focus is to understand the molecular mechanisms of immune-mediated inflammatory diseases.