240 pages | 16 Color Illus.
The scope of the book is to highlight the diverse roles of cilia in human development and disease. Almost all cell types form cilia and although they were first detected about 200 years ago, their significance was unclear. In the past ten years, it has become obvious that cilia have got sensory functions, as well as roles in motility and their mis-formation or the deregulation of the signaling pathways they control has been associated with defective development and human disease. Although research has concentrated on the role of the cilium in each organ, no effort has been made so far to bring all this information together and relate it to the various human diseases. This book aims to gather all the expertise that has been acquired on primary cilia and translate it into a medical and research context that will be of interest to postgraduate students, researchers, medics and scientists.
Cilia in the Brain – Development and Disease
Gilbert Lauter, Peter Swoboda and Isabel Tapia-Páez
Cilia in Lung Development and Disease
Laura L. Yates, Hannah M. Mitchison and Charlotte H. Dean
The Role of Cilia in Heart Development and Disease
Sigolène M. Meilhac
Cilia in Kidney Development and Disease
The Role of Cilia in Pancreatic Development and Disease
Jantje M. Gerdes
The Role of Cilia in Skeletal Development and Disease
The Role of Cilia in Development and Disease of the Eye
S. Patnaik, V. Kretschmer and H. May-Simera
The Role of Cilia in the Auditory System