Clinical Biochemistry and Drug Development : From Fundamentals to Output book cover
1st Edition

Clinical Biochemistry and Drug Development
From Fundamentals to Output

Edited By

Shashank Kumar

ISBN 9781771888691
Published November 2, 2020 by Apple Academic Press
264 Pages 22 Color & 6 B/W Illustrations

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Book Description

This new volume focuses on clinical biochemistry fundamentals, cell culture techniques, and drug discovery and development concepts. It deals with three different fields of clinical research: cell culture, clinical biochemistry, and drug discovery and development.

The book introduces cell animal and bacterial culture techniques and their potential uses as well as cell culture techniques. The biochemistry aspect of the book covers the principles of clinical biochemistry and biochemical analysis, biochemical aids to clinical diagnosis, measurement, and quality control. The book also presents important concepts in cell membrane receptor signal transduction pathways as drug targets.

The drug development focus of the book discusses the fundamentals of human disease and drug discovery. Various in silico, in vitro, and in vivo approaches for drug discovery are examined, along with a discussion on drug delivery carriers and clinical trials. Overall, the volume provides an overview of the journey from clinical fundamentals to clinical output.

Table of Contents

1. An Introduction to Cell Culture

Amit Kumar Sharma, Atul Kumar Singh, and Shashank Kumar

2. Animal Cell Culture

Amit Kumar Sharma et al.

3. Bacterial Cell Culture

Amit Kumar Sharma, Santosh Kumar Maurya, and Shashank Kumar

4. Potential Use of Cell Cultures

Amit Kumar Sharma et al.

5. Principles of Clinical Biochemistry and Biochemical Analysis

Shashank Kumar

6. Biochemical Aids to Clinical Diagnosis

Prem Prakash Kushwaha et al.

7. Clinical Measurements and Quality Control

Prem Prakash Kushwaha et al.

8. Cell Membrane Receptor

Prem Prakash Kushwaha, Swastika Dash, Atul Kumar Singh, and Shashank Kumar

9. Mechanisms of Signal Transduction

Prem Prakash Kushwaha et al.

10. Human Disease Drug Therapy and Drug Discovery

Prem Prakash Kushwaha et al.

11. Drug Development: In Silico, In Vivo and System Biology Approach

Prem Prakash Kushwaha et al.

12. Drug Development: Drug Delivery Carriers and Clinical Trial

Prem Prakash Kushwaha et al.

13. Role of Micro RNA in Prostate Cancer Therapy

Mohammad Waseem Hadiya Husain and Imran Ahmad

14. Pathogenesis, Molecular Mechanisms of Progression, and Therapeutic Targets of Liver Fibrosis: An Update

Hadiya Husain and Riaz Ahmad

15. Prostate Cancer: Molecular Aspects, Biomarkers, and Chemo-Preventive Agents

Risha Ganguly et al.

16. Overview of Tuberculosis Biomarkers: An Update

Abhilasha Tripathi et al.


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Shashank Kumar, PhD, is an Assistant Professor in the Department of Biochemistry and Microbial Sciences at the Central University of Punjab, India. He previously worked as a postdoctoral fellow at the Department of Biochemistry at King George’s Medical University, India. Dr. Kumar has edited several books, including Concepts in Cell Signaling; Secondary Metabolites and Functional Food Components; Carbohydrate Metabolism Theory and Practical Approach; Phytochemistry: An in silico and in vitro Update; among others. Dr. Kumar has published more than 30 scientific papers, reviews, and editorial articles in various national and international journals. He has expertise in the areas of free radical biology, cancer biology, cell culture techniques, characterization of plant products, xenobiotic metabolism, and microbiology. He has presented his research findings at more than 25 national and international conferences and has attended many workshops at many major universities and medical colleges throughout India. Dr. Kumar is an editorial board member and reviewer for about 25 international journals. He is a lifetime member of the Italo-Latin American Society of Ethnomedicine and the Indian Sciences Congress Association and is also a member of Publication Integrity & Ethics, London, UK. Dr. Kumar received his BSc, MSc, and PhD degrees in biochemistry from the Department of Biochemistry, University of Allahabad, India.