Clinical Toxicology: Principles and Mechanisms, Second Edition, 2nd Edition (Hardback) book cover

Clinical Toxicology

Principles and Mechanisms, Second Edition, 2nd Edition

By Frank A. Barile

CRC Press

482 pages | 50 B/W Illus.

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Hardback: 9781420092257
pub: 2010-02-15
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pub: 2010-02-15
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Examining the complex interactions associated with clinical toxicological events and chemical exposure of drug administration, this updated and revised Second Edition functions as a stand-alone text or reference of clinical toxicology for professionals, students of toxicology and pharmacy, as well as forensic toxicologists, occupational healthcare workers, industrial hygienists, and safety engineers. This all-inclusive source has been updated to include the latest issues and the most current research in clinical toxicology.

Key features in Clinical Toxicology: Principles and Mechanisms include:

  • Convenient and organized categorization of compounds into therapeutic and non-therapeutic agents
  • Tables, drawings, and figures that provide readily accessible, precise data
  • Tables for easy usage and cross-reference to names, indications, effects, adverse reactions, and drug interactions for over 70 common herbal products
  • The brand, generic, and street names of therapeutic agents

Topics covered in the Second Edition include:

  • Symptoms of diseases and pathology caused by toxins and clinical drugs
  • Biological and chemical toxins, changes in protocols for managing toxic ingestions, new antidotes, changes in treatments, and the pharmacology and toxicology of herbal products
  • The effects of biological and chemical agents cited by the U.S. and U.N. as potential bioterrorist weapons
  • General physiology and pharmacology principles
  • The widely distributed chemical agents and currently used therapeutic drugs that have hazardous effects

Table of Contents




Introduction to Basic Toxicological Principles


Risk Assessment and Regulatory Toxicology

Therapeutic Monitoring of Adverse Drug Reactions

Classification of Toxins in Humans



Dose Response

Descriptive Animal Toxicity Tests

In Vitro Alternatives to Animal Toxicity


Chemical and Drug Receptor Interactions-Zacharoula Konsoula

Toxicogenomics-Zacharoula Konsoula

Toxicity of Therapeutic Agents


Opioids and Derivatives


Hallucinogenic Agents

Anticholinergic and Neuroleptic Drugs

Acetaminophen, Salicylates, and Nonsteroidal Anti-inflammatory Drugs

Anabolic-Androgenic Steroids

Cardiovascular Toxicology

Antineoplastic Agents


Herbal Remedies

Toxicity of Non-Therapeutic Agents

Alcohols and Aldehydes


Metals-Louis D. Trombetta and Frank A. Barile

Aliphatic and Aromatic Hydrocarbons




Chemical Carcinogenesis and Mutagenesis

Reproductive and Developmental Toxicity

Radiation Toxicity

Chemical and Biological Threats to Public Safety


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
MEDICAL / Toxicology