Clinical Tuberculosis: 6th Edition (Hardback) book cover

Clinical Tuberculosis

6th Edition

Edited by Lloyd N. Friedman, Martin Dedicoat, Peter D. O. Davies

CRC Press

504 pages | 33 Color Illus. | 117 B/W Illus.

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Hardback: 9780815370239
pub: 2020-08-27
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Entirely updated and revised, the 6th edition of Clinical Tuberculosis continues to provide the TB physician with a definitive and erudite account of the latest techniques in diagnosis, treatment and control of TB, including an overview of the latest guidelines from the CDC and WHO. With an increased emphasis on the clinical aspects and treatment, this book will be an invaluable resource to the TB practitioner in public health or clinical practice and an ideal reference to laboratory staff.

Key Features

  • Completely updated and reorganized
  • Includes brand new chapters on radiology and an overview of the latest WHO, ATS/CDC/IDSA, ERS, NICE, CTS and IUATLD guidelines
  • Clinically focused to provide up-to-date guidance on diagnosis, treatment and control
  • Edited by three renowned experts in the field of tuberculosis

Table of Contents

Section I: Background

Ch 1 The History of Tuberculosis from Earliest Times to the Development of Drugs

Charlotte A. Roberts, Jane E. Buikstra

Ch 2 Epidemiology

Grant Theron, Ted Cohen and Christopher Dye

Section II: Pathology and Immunology

Ch 3 Mycobacterium tuberculosis – The Genetic Organism

William R. Jacobs, Jr.

Ch 4 Pathogenesis of Tuberculosis

Divya Reddy and Jerrold J. Ellner

Section III: Transmission

Ch 5 Using Genotyping and Molecular Surveillance to Investigate Tuberculosis Transmission

Sarah Talarico, Laura F. Anderson, and Benjamin J. Silk

Ch 6 Tuberculosis Transmission Control

Edward A. Nardell

Section IV: Diagnosis of Active Disease and Latent Infection

Ch 7 Diagnosis of Active Pulmonary Tuberculosis

J. Lucian Davis

Ch 8 Radiology of Mycobacterial Disease

Anne McB. Curtis, M.D


Ch 9 Diagnosis of Latent TB Infection

Ajit Lalvani, Clementine Fraser and Manish Pareek

Section V: Drugs and Vaccines for Tuberculosis

Ch 10 Clinical Pharmacology of the Anti-tuberculosis drugs

Gerry Davies and Charles Peloquin

Ch 11 New Developments in Drug Treatment

Alexander S. Pym, Camus Nimmo and James Millard

Ch 12 BCG and Other Vaccines

Helen McShane and Rachel Tanner


Section VI: Clinical Aspects and Treatment

Ch 13 Pulmonary Tuberculosis

Charles S. Dela Cruz, Barbara Seaworth and Graham Bothamley

Ch 14 Extrapulmonary Tuberculosis

Charles L. Daley

Ch 15 Tuberculosis and Human Immunodeficiency Virus Co-infection

Charisse Mandimika and Gerald Friedland

Ch 16 Drug Resistant Tuberculosis

Keertan Dheda, Aliasgar Esmail, Anzaan Dippenaar, Robin Warren, Jennifer Furin and Christoph Lange


Ch 17 The Surgical Management of Tuberculosis and Its Complications

Richard S. Steyn

Ch 18 Tuberculosis in Childhood and Pregnancy

Lindsay H. Cameron and Jeffrey R. Starke

Ch 19 Treatment of Latent Tuberculosis Infection Including Risk Factors for the Development of Tuberculosis

Martin Dedicoat

Section VII: Official Statements - Comparison of NICE, WHO and CDC Recommendations

Ch 20 Treatment Guidelines for Active Drug Susceptible and Drug Resistant Pulmonary Tuberculosis and Latent Tuberculosis Infection

Lynn E. Sosa and Lloyd N. Friedman

Section VIII: Control

Ch 21 Tuberculosis Epidemic-Control: A Comprehensive Strategy To Drive Down Tuberculosis

Salmaan Keshavjee, Tom Nicholson, Aamir J. Khan, Lucica Ditiu, Paul E. Farmer and Mercedes C. Becerra

Section IX: Related Aspects

Ch 22 Animal Tuberculosis

Catherine Wilson

About the Editors

Lloyd N. Friedman, M.D., is a Clinical Professor of Pulmonary, Critical Care and Sleep Medicine at the Yale School of Medicine, New Haven, CT. He is Director of Inpatient Quality and Safety for the Department of Internal Medicine. He is a member of the American Thoracic Society, a member of the Society of Critical Care Medicine, a fellow of the American College of Chest Physicians and a member of the International Union Against Tuberculosis and Lung Disease. He is Chairman of the Connecticut Tuberculosis Elimination Advisory Committee.

Martin Dedicoat PhD, FRCP, BSc, DTM&H is a Consultant physician in infectious diseases at the University Hospitals Birmingham. He is currently clinical lead for tuberculosis for Birmingham and Solihull, UK. His main research interests center around tuberculosis transmission in urban settings. Dr Dedicoat is a member of the British Thoracic Society drug resistant tuberculosis management group advising on management of complex tuberculosis patients across the UK. He also sits on the National Tuberculosis board for England.

Dr. Peter D. O. Davies graduated in 1966 from Marlborough College, Wilts, UK and obtained his BM, BCh and MA from University College, Oxford, UK in 1971 and St. Thomas’s Hospital in London in 1973. He gained a DM from oxford in 1984. He was a Consultant General and Respiratory Physician at Aintree University Hospital from 1988 to 2011 and at Liverpool Heart Chest Hospital from 1988 to 2015. He is or has been a member of the British Medical Association, the British Thoracic Society, the European Respiratory Society, the Royal College of Physicians of London (Fellow), the Royal Society of Medicine, the American Thoracic Society, the North Western Society of Respiratory Physicians where he served as President in 2007, the International Union Against Tuberculosis and Lung Disease where he was Chair of the Tuberculosis Section, President of the European section, and Editor in Chief of the International Journal of Tuberculosis and Lung Disease, and a member of NICE where he was chair of the Tuberculosis Section. He co-founded the UK Based TB charity in 1998. Dr. Davies is an expert in tuberculosis and edited the inaugural edition of the textbook, Clinical Tuberculosis in 1994 and has continued as editor for the subsequent 5 editions.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / General
MEDICAL / Infectious Diseases
MEDICAL / Public Health
MEDICAL / Pulmonary & Thoracic Medicine