This book brings together for the first time state-of-the-art research from both the basic sciences and the clinical fields to present an in-depth discussion of the numerous effects of cocaine. The issues discussed include metabolism and distribution of cocaine, behavioral and electrophysiological actions of cocaine, clinical aspects of cocaine associated with addiction and abuse on cardiovascular function, and exposure of infants to cocaine during gestation. The unique, multidisciplinary perspective of this book regarding on-going research on cocaine and drug abuse will be useful to researchers, clinicians, health care practitioners, and graduate students who need to stay abreast of the most current information available on this drug.
Pharmacokinetics, Metabolism, and Disposition of Cocaine. Cocaine-Induced Hepatotoxicity. Metabolic Mapping of the Effects of Cocaine in the Brain. Brain-Stimulation Reward as a Model of Drug-Induced Euphoria: Comparison of Cocaine and Opiates. Neural Substrates Mediating Cocaine Reinforcement: The Role of Monoamine Systems. Neurobiological Mechanisms of the Reinforcing and Discriminative Stimulus Properties of Cocaine. Sensitization and Kindling Effects of Chronic Cocaine Administration. Neuropharmacology of Cocaine: Effects on Dopamine and Seratonin Systems. A Cocaine Receptor Associated with Dopamine Transport and Drug Self-Administration. Central and Peripheral Cocaine Binding Sites. Neurochemical Mechanisms of Cocaine-Induced Sensitization. Electrophysiologic Effects of Cocaine within the Mesoaccumbens and Mesocortical Dopamine Systems. Electrophysiological Effects of Cocaine on Serotonin Neuronal Systems. In Vitro Approaches to Characterizing the Electrophysiological Effects of Cocaine upon the Central Nervous System. Neuroendocrine Effects of Cocaine. Effects of Cocaine and Other Drugs of Abuse on Immune Responses. Underlying Mechanisms Responsible for Cardiovascular Disorders Associated with Cocaine Abuse. Perinatal Exposure to Cocaine: Human Studies. Treatment Strategies for Cocaine Detoxification.