Color Atlas of Nerve Biopsy Pathology: 1st Edition (Hardback) book cover

Color Atlas of Nerve Biopsy Pathology

1st Edition

By Shin J. Oh

CRC Press

296 pages | 255 B/W Illus.

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pub: 2001-08-29
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Description

As a professional working in the frontlines of tissue diagnosis and in everyday practice, you need a reference that gives you practical information in an easy-to-use format. Containing over 300 photographs, micrographs, and line drawings, including over 60 color illustrations, Color Atlas of Nerve Biopsy Pathology supplies a clear picture of commonly used techniques for nerve biopsies. You get new diagnostic techniques and clinicopathological correlations all in a framework designed for quick reference and easy learning.

Providing all the practical information you need from A to Z, Color Atlas of Nerve Biopsy Pathology describes how to:

  • perform a nerve biopsy

  • handle specimens

  • process the nerve by frozen sections, by paraffin sections, and by semi-thin sections

    The book delineates the general pathological features of peripheral nerve disorders and the diagnostic capability and limitations of the nerve biopsy. It details the typical pathological features of each disease by presenting color photographs and example cases that provide a brief clinical history and pertinent electrophysiological and other laboratory data. The exhaustively illustrated color format provides you with immediate information in reaching a definitive diagnosis.

    Unlike other books on this subject, this one contains frozen section materials, case histories, teased nerve illustrations, and newly described neuropathies. The author brings twenty-five years of experience in the lab and teaching to the development of this atlas. In the lab or in the classroom, on the front lines of tissue diagnosis, Color Atlas of Nerve Biopsy Pathology provides you with the information you need clearly, concisely, and conveniently.

  • Reviews

    " …an authoritative and well-illustrated peripheral neuropathy reference source that is more clinically oriented that other nerve pathology atlases. The combination of clinical information and the detailed descriptions of pathogenic mechanisms help the pathologist correlate clinical with pathologic findings."

    - Karen Sterling SantaCruz, MD, University of Kansas School of Medicine, in Doody's Notes

    Table of Contents

    GENERAL CONCEPTS OF PERIPHERAL NEUROPATHY

    Classification of Peripheral Neuropathy

    Basic Pathological Mechanism

    Etiologies of Peripheral Neuropathy

    Types of Neuropathies

    Symptoms and Signs

    Diagnostic Investigations

    Nerve Conduction Studies and Needle Electromyography

    Laboratory Studies

    THE NERVE BIOPSY

    Indication for the Nerve Biopsy

    Types of Nerve Biopsy

    Sural Nerve Biopsy

    Sequelae of Nerve Biopsy

    Biopsy of Other Nerves

    HISTOLOGICAL PROCESSING AND STAINING OF THE BIOPSIED NERVE

    Treatment of the Biopsied Nerve

    Immediate Care of the Biopsied Nerve

    Processing of the Nerve

    Paraffin Section Stainings

    Frozen Section Stainings

    Processing of the Nerve for Semithin and Electron Microscopy Sections

    Semithin (0.5 - 1mm) Section Stainings

    Nerve Fiber Teasing

    Electron Microscope Study

    NORMAL NERVE: HISTOLOGY

    Age-Related Changes in the Sural Nerve Biopsy

    SPECIFIC DIAGNOSTIC PATHOLOGICAL FEATURES OF NERVE BIOPSY

    Vasculitis

    Amyloid Deposits

    Metachromatic Granules

    Polyglucosan Body

    Onion-Bulb Formation

    Inflammatory Cells and Segmental Demyelination

    INFLAMMATORY CELLS AND AXONAL DEGENERATION

    Noncaseating Granuloma

    Necrotizing (Caseating) Granuloma

    Giant Axons

    Tomacula

    Occlusion of Vasa Nervorum

    Malignant Cells

    IgM Deposits

    Segmental Demyelination

    Axonal Degeneration

    VASCULITIC NEUROPATHY

    Vulnerability of the Peripheral Nerve to Vasculitic neuropathy

    Clinical, Electromyographic, and Laboratory Features

    Diagnostic Sensitivity of Nerve and Muscle Biopsies

    Pathology of Vasculitic Neuropathy

    Pathogenesis of Vasculitic Neuropathy

    Systemic Necrotizing Vasculitides

    Vasculitis Associated with Connective Tissue Diseases

    Nonsystemic Vasculitic Neuropathy

    Vasculitis in Other Diseases

    Cases with Vasculitic Neuropathy

    INFLAMMATORY DEMYELINATING NEUROPATHY

    Pathogenesis of Inflammatory Demyelinating Neuropathies

    Guillain-Barré Syndrome (Acute inflammatory Demyelinating Polyneuropathy; AIDP)

    Variants of GBS

    Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

    Multifocal Motor Neuropathy (MMN)

    Multifocal Motor Sensory Demyelinating Neuropathy (MMSDN)

    Chronic Sensory Demyelinating Neuropathy (CSDN)

    Cases of Inflammatory Demyelinating Neuropathy

    IMMUNE-MEDIATED NEUROPATHIES

    GM1 Antibody-Positive Neuropathy

    Anti-MAG Associated Neuropathy

    Neuropathy Associated with Anti-Hu (ANNA 1) Antibody

    Neuropathy with Monoclonal Gammopathy

    Cases of Immune-Mediated Neuropathy

    NEUROPATHIES WITH ABNORMAL DEPOSITS

    Amyloid Neuropathy

    Metachromatic Leukodystrophy (Sulfatide Lipidosis; Arylsulfatidase Deficiency)

    Polyglucosan Body Neuropathy

    Fabry's Disease (Alpha-Galactosidase-A Deficiency)

    Adrenomyeloneuropathy (AMN)

    Cases of Neuropathy with Abnormal Deposit

    HEREDITARY NEUROPATHIES

    Hereditary Motor and Sensory Neuropathies (HMSN)

    Hereditary Sensory Neuropathy

    Hereditary Neuropathy to Pressure Palsy (HNPP)

    Giant Axonal Neuropathy (GAN)

    Friedreich's Ataxia

    METABOLIC AND SYSTEMIC NEUROPATHIES

    Sarcoid Neuropathy

    Sensory Perineuritis

    Leprosy

    Lymphomatous Neuropathy

    Diabetic Neuropathy

    Uremic Neuropathy

    Alcoholic Neuropathy

    Hypothyroid Neuropathy

    Vitamin B12 Deficiency Neuropathy

    Pyridoxine-Induced Sensory Neuropathy

    Polyradiculoneuropathy in Lyme Disease

    AIDS Neuropathy

    TOXIC NEUROPATHIES

    Metal Neuropathies

    Drug-Induced Neuropathy

    Neuropathy Due to Biological Toxins and Vaccines

    Toxic Neuropathy Due to Industrial and Environmental Agents

    Epidemic Toxic Inflammatory Neuropathies

    Cases of Toxic Neuropathies

    INTERPRETATION OF NERVE BIOPSY

    INDEX

    References are included at the end of each chapter.

    Subject Categories

    BISAC Subject Codes/Headings:
    MED000000
    MEDICAL / General
    MED056000
    MEDICAL / Neurology
    MED067000
    MEDICAL / Pathology
    SCI089000
    SCIENCE / Life Sciences / Neuroscience