Color Atlas of Nerve Biopsy Pathology  book cover
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1st Edition

Color Atlas of Nerve Biopsy Pathology




ISBN 9780849316760
Published August 29, 2001 by CRC Press
296 Pages - 255 B/W Illustrations

 
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Book Description

As a professional working in the frontlines of tissue diagnosis and in everyday practice, you need a reference that gives you practical information in an easy-to-use format. Containing over 300 photographs, micrographs, and line drawings, including over 60 color illustrations, Color Atlas of Nerve Biopsy Pathology supplies a clear picture of commonly used techniques for nerve biopsies. You get new diagnostic techniques and clinicopathological correlations all in a framework designed for quick reference and easy learning.


Providing all the practical information you need from A to Z, Color Atlas of Nerve Biopsy Pathology describes how to:

  • perform a nerve biopsy
  • handle specimens
  • process the nerve by frozen sections, by paraffin sections, and by semi-thin sections

    The book delineates the general pathological features of peripheral nerve disorders and the diagnostic capability and limitations of the nerve biopsy. It details the typical pathological features of each disease by presenting color photographs and example cases that provide a brief clinical history and pertinent electrophysiological and other laboratory data. The exhaustively illustrated color format provides you with immediate information in reaching a definitive diagnosis.

    Unlike other books on this subject, this one contains frozen section materials, case histories, teased nerve illustrations, and newly described neuropathies. The author brings twenty-five years of experience in the lab and teaching to the development of this atlas. In the lab or in the classroom, on the front lines of tissue diagnosis, Color Atlas of Nerve Biopsy Pathology provides you with the information you need clearly, concisely, and conveniently.
  • Table of Contents

    GENERAL CONCEPTS OF PERIPHERAL NEUROPATHY
    Classification of Peripheral Neuropathy
    Basic Pathological Mechanism
    Etiologies of Peripheral Neuropathy
    Types of Neuropathies
    Symptoms and Signs
    Diagnostic Investigations
    Nerve Conduction Studies and Needle Electromyography
    Laboratory Studies

    THE NERVE BIOPSY
    Indication for the Nerve Biopsy
    Types of Nerve Biopsy
    Sural Nerve Biopsy
    Sequelae of Nerve Biopsy
    Biopsy of Other Nerves

    HISTOLOGICAL PROCESSING AND STAINING OF THE BIOPSIED NERVE
    Treatment of the Biopsied Nerve
    Immediate Care of the Biopsied Nerve
    Processing of the Nerve
    Paraffin Section Stainings
    Frozen Section Stainings
    Processing of the Nerve for Semithin and Electron Microscopy Sections
    Semithin (0.5 - 1mm) Section Stainings
    Nerve Fiber Teasing
    Electron Microscope Study

    NORMAL NERVE: HISTOLOGY
    Age-Related Changes in the Sural Nerve Biopsy

    SPECIFIC DIAGNOSTIC PATHOLOGICAL FEATURES OF NERVE BIOPSY
    Vasculitis
    Amyloid Deposits
    Metachromatic Granules
    Polyglucosan Body
    Onion-Bulb Formation
    Inflammatory Cells and Segmental Demyelination
    INFLAMMATORY CELLS AND AXONAL DEGENERATION
    Noncaseating Granuloma
    Necrotizing (Caseating) Granuloma
    Giant Axons
    Tomacula
    Occlusion of Vasa Nervorum
    Malignant Cells
    IgM Deposits
    Segmental Demyelination
    Axonal Degeneration

    VASCULITIC NEUROPATHY
    Vulnerability of the Peripheral Nerve to Vasculitic neuropathy
    Clinical, Electromyographic, and Laboratory Features
    Diagnostic Sensitivity of Nerve and Muscle Biopsies
    Pathology of Vasculitic Neuropathy
    Pathogenesis of Vasculitic Neuropathy
    Systemic Necrotizing Vasculitides
    Vasculitis Associated with Connective Tissue Diseases
    Nonsystemic Vasculitic Neuropathy
    Vasculitis in Other Diseases
    Cases with Vasculitic Neuropathy

    INFLAMMATORY DEMYELINATING NEUROPATHY
    Pathogenesis of Inflammatory Demyelinating Neuropathies
    Guillain-Barré Syndrome (Acute inflammatory Demyelinating Polyneuropathy; AIDP)
    Variants of GBS
    Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
    Multifocal Motor Neuropathy (MMN)
    Multifocal Motor Sensory Demyelinating Neuropathy (MMSDN)
    Chronic Sensory Demyelinating Neuropathy (CSDN)
    Cases of Inflammatory Demyelinating Neuropathy

    IMMUNE-MEDIATED NEUROPATHIES
    GM1 Antibody-Positive Neuropathy
    Anti-MAG Associated Neuropathy
    Neuropathy Associated with Anti-Hu (ANNA 1) Antibody
    Neuropathy with Monoclonal Gammopathy
    Cases of Immune-Mediated Neuropathy

    NEUROPATHIES WITH ABNORMAL DEPOSITS
    Amyloid Neuropathy
    Metachromatic Leukodystrophy (Sulfatide Lipidosis; Arylsulfatidase Deficiency)
    Polyglucosan Body Neuropathy
    Fabry's Disease (Alpha-Galactosidase-A Deficiency)
    Adrenomyeloneuropathy (AMN)
    Cases of Neuropathy with Abnormal Deposit

    HEREDITARY NEUROPATHIES
    Hereditary Motor and Sensory Neuropathies (HMSN)
    Hereditary Sensory Neuropathy
    Hereditary Neuropathy to Pressure Palsy (HNPP)
    Giant Axonal Neuropathy (GAN)
    Friedreich's Ataxia

    METABOLIC AND SYSTEMIC NEUROPATHIES
    Sarcoid Neuropathy
    Sensory Perineuritis
    Leprosy
    Lymphomatous Neuropathy
    Diabetic Neuropathy
    Uremic Neuropathy
    Alcoholic Neuropathy
    Hypothyroid Neuropathy
    Vitamin B12 Deficiency Neuropathy
    Pyridoxine-Induced Sensory Neuropathy
    Polyradiculoneuropathy in Lyme Disease
    AIDS Neuropathy

    TOXIC NEUROPATHIES
    Metal Neuropathies
    Drug-Induced Neuropathy
    Neuropathy Due to Biological Toxins and Vaccines
    Toxic Neuropathy Due to Industrial and Environmental Agents
    Epidemic Toxic Inflammatory Neuropathies
    Cases of Toxic Neuropathies

    INTERPRETATION OF NERVE BIOPSY

    INDEX

    References are included at the end of each chapter.

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    Reviews

    " …an authoritative and well-illustrated peripheral neuropathy reference source that is more clinically oriented that other nerve pathology atlases. The combination of clinical information and the detailed descriptions of pathogenic mechanisms help the pathologist correlate clinical with pathologic findings."
    - Karen Sterling SantaCruz, MD, University of Kansas School of Medicine, in Doody's Notes