1st Edition

Comprehensive Brachytherapy Physical and Clinical Aspects

    536 Pages 35 Color & 262 B/W Illustrations
    by CRC Press

    536 Pages 35 Color & 262 B/W Illustrations
    by CRC Press

    535 Pages 35 Color & 262 B/W Illustrations
    by CRC Press

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    Modern brachytherapy is one of the most important oncological treatment modalities requiring an integrated approach that utilizes new technologies, advanced clinical imaging facilities, and a thorough understanding of the radiobiological effects on different tissues, the principles of physics, dosimetry techniques and protocols, and clinical expertise. A complete overview of the field, Comprehensive Brachytherapy: Physical and Clinical Aspects is a landmark publication, presenting a detailed account of the underlying physics, design, and implementation of the techniques, along with practical guidance for practitioners.

    Bridging the gap between research and application, this single source brings together the technological basis, radiation dosimetry, quality assurance, and fundamentals of brachytherapy. In addition, it presents discussion of the most recent clinical practice in brachytherapy including prostate, gynecology, breast, and other clinical treatment sites. Along with exploring new clinical protocols, it discusses major advances in imaging, robotics, dosimetry, Monte Carlo-based dose calculation, and optimization.

    Introduction and Innovations in Brachytherapy
    Jack Venselaar, Dimos Baltas, Peter Hoskin, and Ali S. Meigooni
    Standard Technology in Brachytherapy
    Rupak Das and Jack Venselaar
    Radionuclides in Brachytherapy: Current and Potential New Sources
    Facundo Ballester, Ravinder Nath, and Dimos Baltas
    Quality Assurance of Equipment
    Jack Venselaar and Firas Mourtada

    Brachytherapy Dosimetry
    Source Calibration
    Hans Bjerke, Larry DeWerd, Jan Seuntjens, and Margaret Bidmead
    Experimental Dosimetry Methods
    Dimos Baltas, Brigitte Reniers, and Ali S. Meigooni
    Computational Methods for Dosimetric Characterization of Brachytherapy Sources
    Panagiotis Papagiannis, Luc Beaulieu, and Firas Mourtada

    Brachytherapy Treatment Planning and Imaging
    Historical Development of Predictive Dosimetry "Systems"
    Ali S. eigooni, Margaret Bidmead, and Jack Venselaar
    Two-, Three-, and Four-Dimensional Brachytherapy
    Jean Pouliot, Ron Sloboda, and Brigitte Reniers
    TG-Dose Calculation Formalism: Development, Insights, and Modernization
    Mark Rivard, Ali Soleimani-Meigooni, and Ravinder Nath
    On the Introduction of Model-Based Algorithms Performing Nonwater Heterogeneity Corrections into Brachytherapy Treatment Planning
    Åsa Carlsson Tedgren, Frank Verhaegen, and Luc Beaulieu
    Optimization and Evaluation
    Dimos Baltas and Inger-Karine Kolkman-Deurloo
    Quality Management of Treatment Planning
    Ali S. Meigooni, and Jack Venselaar
    Practical Use, Limitations, and Quality Control of Imaging in Brachytherapy
    Frank-André Siebert and Taran Paulsen Hellebust

    Uncertainties in Clinical Brachytherapy
    Uncertainties Associated with Brachytherapy Source Calibrations and Dose Calculations
    Larry DeWerd, Mark Rivard, and Hans-Joachim Selbach
    Uncertainties Associated with Clinical Aspects of Brachytherapy
    Peter Hoskin, Alfredo Polo, and Jack Venselaar
    Margin Concepts in Image-Guided Brachytherapy
    Kari Tanderup, Christian Kirisits, Jacob Lindegaard, Erik van Limbergen, André Wambersie, and Richard Pötter

    Clinical Brachytherapy
    Clinical Use of Brachytherapy
    Peter Hoskin
    Radiobiology for Brachytherapy
    David Carlson, Zhe Chen, Peter Hoskin, Zoubir Ouhib, and Marco Zaider
    Brachytherapy for Prostate Cancer
    Alfredo Polo and Michel Ghilezan
    Brachytherapy for Gynecologic Cancers
    Beth Erickson, Mahesh Kudrimoti, and Christine Haie-Meder
    Brachytherapy for Breast Cancer
    Kara Lynne Leonard and Erik Van Limbergen
    Brachytherapy for Other Treatment Sites
    Vratislav Strnad, Beth Erickson, and Mahesh Kudrimoti

    Developments in Clinical Brachytherapy
    Developments in Gynecologic Brachytherapy Dose Recording and Reporting: From ICRU Report to Image-Guided Brachytherapy
    John Mignano
    In Vivo Dosimetry in Brachytherapy
    Joanna Cygler, Kari Tanderup, Sam Beddar, and José Pérez-Calatayud
    Special Brachytherapy Modalities
    Christopher Melhus, Mark Rivard, and Ravinder Nath
    Advanced Brachytherapy Technologies: Encapsulation, Ultrasound, and Robotics
    Mark Rivard, Luc Beaulieu, and Marinus Moerland
    Intraoperative Brachytherapy
    Joost Jan Nuyttens and Subir Nag

    Radiation Protection and Quality Management in Brachytherapy
    Radiation Protection in Brachytherapy
    Panagiotis Papagiannis and Ning Yue
    New Paradigm for Quality Management in Brachytherapy
    Susan Richardson, Geethpriya Palaniswaamy, Sasa Mutic, and Eric Klein
    Quality Audits in Brachytherapy
    Carlos de Almeida, David Followill, and Claudio Sibata
    Expert Training in Brachytherapy
    Alex Rijnders, Zoubir Ouhib, György Kovács, and Peter Grimm


    Ali S. Meigooni, Jack Venselaar, Dimos Baltas, Peter J. Hoskin

    "The editors, all very accomplished and extremely knowledgeable of the field, assembled a fine collection of authors to write on the widely varied topics. … a very good compilation on brachytherapy physics and the current state of the practice …"
    —Bruce Thomadsen, Medical Physics, November 2013

    "… an excellent reference text which represents the current status of brachytherapy for all clinical sites and sets the scene for how it will continue to progress. Readers will be particularly pleased to find discussions on margin concepts, radiobiology and 3- and 4-D imaging modalities for planning, as well as a thorough review of a range of modern techniques. … The amount of detail included is extensive … Excellent references are given throughout. … This will certainly be a key reference for today’s brachytherapy centres."
    SCOPE, March 2013

    "This book … addresses the topic of brachytherapy from many vantage points, oncological, physical, and biological, and will satisfy readers from the entire radiotherapy community."
    —From the Foreword by Pierre Scalliet

    "Certainly, the frontier has been pushed in several directions and Comprehensive Brachytherapy covers some of these well… Overall, it is a very good compilation of brachytherapy physics and the current state of the practice…"
    —Bruce Robert Thomadsen, Ph.D., University of Wisconsin-Madison, USA