Comprehensive Brachytherapy: Physical and Clinical Aspects, 1st Edition (Paperback) book cover

Comprehensive Brachytherapy

Physical and Clinical Aspects, 1st Edition

Edited by Jack Venselaar, Ali S. Meigooni, Dimos Baltas, Peter J. Hoskin

CRC Press

535 pages | 35 Color Illus. | 262 B/W Illus.

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Modern brachytherapy is one of the most important oncological treatment modalities requiring an integrated approach that utilizes new technologies, advanced clinical imaging facilities, and a thorough understanding of the radiobiological effects on different tissues, the principles of physics, dosimetry techniques and protocols, and clinical expertise. A complete overview of the field, Comprehensive Brachytherapy: Physical and Clinical Aspectsis a landmark publication, presenting a detailed account of the underlying physics, design, and implementation of the techniques, along with practical guidance for practitioners.

Bridging the gap between research and application, this single source brings together the technological basis, radiation dosimetry, quality assurance, and fundamentals of brachytherapy. In addition, it presents discussion of the most recent clinical practice in brachytherapy including prostate, gynecology, breast, and other clinical treatment sites. Along with exploring new clinical protocols, it discusses major advances in imaging, robotics, dosimetry, Monte Carlo-based dose calculation, and optimization.


"The editors, all very accomplished and extremely knowledgeable of the field, assembled a fine collection of authors to write on the widely varied topics. … a very good compilation on brachytherapy physics and the current state of the practice …"

—Bruce Thomadsen, Medical Physics, November 2013

"… an excellent reference text which represents the current status of brachytherapy for all clinical sites and sets the scene for how it will continue to progress. Readers will be particularly pleased to find discussions on margin concepts, radiobiology and 3- and 4-D imaging modalities for planning, as well as a thorough review of a range of modern techniques. … The amount of detail included is extensive … Excellent references are given throughout. … This will certainly be a key reference for today’s brachytherapy centres."

SCOPE, March 2013

"This book … addresses the topic of brachytherapy from many vantage points, oncological, physical, and biological, and will satisfy readers from the entire radiotherapy community."

—From the Foreword by Pierre Scalliet

"Certainly, the frontier has been pushed in several directions and Comprehensive Brachytherapy covers some of these well… Overall, it is a very good compilation of brachytherapy physics and the current state of the practice…"

—Bruce Robert Thomadsen, Ph.D., University of Wisconsin-Madison, USA

Table of Contents


Introduction and Innovations in Brachytherapy

Jack Venselaar, Dimos Baltas, Peter Hoskin, and Ali S. Meigooni

Standard Technology in Brachytherapy

Rupak Das and Jack Venselaar

Radionuclides in Brachytherapy: Current and Potential New Sources

Facundo Ballester, Ravinder Nath, and Dimos Baltas

Quality Assurance of Equipment

Jack Venselaar and Firas Mourtada

Brachytherapy Dosimetry

Source Calibration

Hans Bjerke, Larry DeWerd, Jan Seuntjens, and Margaret Bidmead

Experimental Dosimetry Methods

Dimos Baltas, Brigitte Reniers, and Ali S. Meigooni

Computational Methods for Dosimetric Characterization of Brachytherapy Sources

Panagiotis Papagiannis, Luc Beaulieu, and Firas Mourtada

Brachytherapy Treatment Planning and Imaging

Historical Development of Predictive Dosimetry "Systems"

Ali S. eigooni, Margaret Bidmead, and Jack Venselaar

Two-, Three-, and Four-Dimensional Brachytherapy

Jean Pouliot, Ron Sloboda, and Brigitte Reniers

TG-Dose Calculation Formalism: Development, Insights, and Modernization

Mark Rivard, Ali Soleimani-Meigooni, and Ravinder Nath

On the Introduction of Model-Based Algorithms Performing Nonwater Heterogeneity Corrections into Brachytherapy Treatment Planning

Åsa Carlsson Tedgren, Frank Verhaegen, and Luc Beaulieu

Optimization and Evaluation

Dimos Baltas and Inger-Karine Kolkman-Deurloo

Quality Management of Treatment Planning

Ali S. Meigooni, and Jack Venselaar

Practical Use, Limitations, and Quality Control of Imaging in Brachytherapy

Frank-André Siebert and Taran Paulsen Hellebust

Uncertainties in Clinical Brachytherapy

Uncertainties Associated with Brachytherapy Source Calibrations and Dose Calculations

Larry DeWerd, Mark Rivard, and Hans-Joachim Selbach

Uncertainties Associated with Clinical Aspects of Brachytherapy

Peter Hoskin, Alfredo Polo, and Jack Venselaar

Margin Concepts in Image-Guided Brachytherapy

Kari Tanderup, Christian Kirisits, Jacob Lindegaard, Erik van Limbergen, André Wambersie, and Richard Pötter

Clinical Brachytherapy

Clinical Use of Brachytherapy

Peter Hoskin

Radiobiology for Brachytherapy

David Carlson, Zhe Chen, Peter Hoskin, Zoubir Ouhib, and Marco Zaider

Brachytherapy for Prostate Cancer

Alfredo Polo and Michel Ghilezan

Brachytherapy for Gynecologic Cancers

Beth Erickson, Mahesh Kudrimoti, and Christine Haie-Meder

Brachytherapy for Breast Cancer

Kara Lynne Leonard and Erik Van Limbergen

Brachytherapy for Other Treatment Sites

Vratislav Strnad, Beth Erickson, and Mahesh Kudrimoti

Developments in Clinical Brachytherapy

Developments in Gynecologic Brachytherapy Dose Recording and Reporting: From ICRU Report to Image-Guided Brachytherapy

John Mignano

In Vivo Dosimetry in Brachytherapy

Joanna Cygler, Kari Tanderup, Sam Beddar, and José Pérez-Calatayud

Special Brachytherapy Modalities

Christopher Melhus, Mark Rivard, and Ravinder Nath

Advanced Brachytherapy Technologies: Encapsulation, Ultrasound, and Robotics

Mark Rivard, Luc Beaulieu, and Marinus Moerland

Intraoperative Brachytherapy

Joost Jan Nuyttens and Subir Nag

Radiation Protection and Quality Management in Brachytherapy

Radiation Protection in Brachytherapy

Panagiotis Papagiannis and Ning Yue

New Paradigm for Quality Management in Brachytherapy

Susan Richardson, Geethpriya Palaniswaamy, Sasa Mutic, and Eric Klein

Quality Audits in Brachytherapy

Carlos de Almeida, David Followill, and Claudio Sibata

Expert Training in Brachytherapy

Alex Rijnders, Zoubir Ouhib, György Kovács, and Peter Grimm

About the Series

Imaging in Medical Diagnosis and Therapy

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Oncology
SCIENCE / Physics