1st Edition

Computational Methods for Reproductive and Developmental Toxicology

Edited By

Donald R. Mattison

ISBN 9781439861073
Published December 8, 2015 by CRC Press
344 Pages 52 B/W Illustrations

USD $170.00

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Book Description

Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology.

The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development.

The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods.

The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.

Table of Contents



Donald R. Mattison

Visions and Advancements for Meeting the Needs of Safety Assessment of Pharmaceutical and Industrial Chemicals

Karen A. Augustine-Rauch

REACH and Environmental Chemicals

Olivier Taboureau, Karine Audouze, and Søren Brunak


Female Reproductive Physiology

Mariangela Maluf and Paulo Marcelo Perin

Maternal Recognition of Pregnancy

Paulo Marcelo Perin and Mariangela Maluf

Early Embryo Development and Bipotential Gonad Formation

Paulo Marcelo Perin and Mariangela Maluf

Assessing the Reproductive Health of Men with Occupational Exposures

Steven M. Schrader, Susan Reutman, and Katherine L. Marlow


Animal Study Protocols and Alternative Assays for the Assessment of Reproductive and Developmental Toxicity

Aldert H. Piersma

US National Library of Medicine Resources for Computational Toxicology

Pertti J. Hakkinen

Modeling Endocrine Regulation of the Menstrual Cycle Using Delay Differential Equations

Leona A. Harris and James F. Selgrade

Molecular Structural Characteristics That Influence Partitioning of Xenobiotics into Human Breast Milk

Snezana Agatonovic-Kustrin and David W. Morton

Approaches for Pediatric Developmental Drug-Induced Liver Injury

William F. Salminen and Xi Yang

Adverse Outcome Pathways for Developmental Toxicity

Damiano Portinari and Philip N. Judson

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Edited by

Donald R. Mattison, National Institutes of Health, Bethesda, Maryland, USA, and Risk Sciences International, Ottawa, Ontario, Canada