Computer Techniques in Preclinical and Clinical Drug Development: 1st Edition (Hardback) book cover

Computer Techniques in Preclinical and Clinical Drug Development

1st Edition

By Robert C. Jackson

CRC Press

256 pages

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Hardback: 9780849376825
pub: 1996-07-23
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Description

It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, "How can we use computational methods to improve the success rate in drug development?" Computer Techniques in Preclinical and Clinical Drug Development shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.

Table of Contents

Introduction: The Preclinical and Clinical Drug Development Process

Physiological Pharmacokinetic Modeling

Interspecies Scaling

Prediction of Drug Metabolism and Toxicity

Pharmacodynamic Modeling

Cytokinetic Modeling

Prediction of Drug Resistance

Conclusions: The Virtual Clinical Trial

References

Appendix: Computational Pharmacology Software Suppliers

Abbreviations

Index

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology