Contemporary IMRT: Developing Physics and Clinical Implementation, 1st Edition (Hardback) book cover

Contemporary IMRT

Developing Physics and Clinical Implementation, 1st Edition

By S. Webb

CRC Press

492 pages

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Hardback: 9780750310048
pub: 2004-10-01
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Description

The most important radiotherapy modality used today, intensity modulated radiation therapy (IMRT), is the most technologically advanced radiotherapy cancer treatment available, rapidly replacing conformal and three-dimensional techniques. Because of these changes, oncologists and radiotherapists need up-to-date information gathered by physicists and engineers. Focusing on new developments and the preliminary clinical implementation, Contemporary IMRT: Developing Physics and Clinical Implementation discusses the relationship between these advances and applications.

Capturing contemporary technological advances, the book reviews modern applications of IMRT and shows how IMRT is used now and how it will be used in the future. The book begins with a historical background of IMRT as well as a discussion of the current state of IMRT. It also covers technical solutions that have been commercialized, such as the sliding window technique, step-and-shoot, tomotherapy, and the Cyberknife. The final chapter explores imaging developments and new planning methods, including gradient-descent and split modulation.

Covering recent advancements in IMRT and showing how these techniques and devices have been implemented, Contemporary IMRT: Developing Physics and Clinical Implementation provides state-of-the-art findings for oncologists, radiotherapists, radiographers, physicists, and engineers.

Reviews

"… the author presents a remarkably exhaustive review of the published material on the physics and clinical implementation of IMRT since the summer of 2000 through June 2004. This is also the author's most recent volume in a series of four on radiation therapy, and his second book devoted exclusively to developments in IMRT. …Overall, this book reviews a vast amount of valuable published material to give the reader an exhaustive and accurate account of developments in the physics and clinical implementation of IMRT over the last four years. It is an excellent review that will serve as a valuable reference for the practicing physicist."

- Medical Physics

"Contemporary IMRT covers the latest developments in the field of intensity modulated radiation therapy between 2000 and 2004, and is a wonderful and exhaustive book with almost 1,500 references, mostly published in this period. The wealth of newly published work makes a review book like this invaluable for anybody who wants to understand and contribute to the exciting world of contemporary radiation therapy…Especially valuable is an extensive review of early clinical IMRT evidence, primarily expressed as reduced toxicity due to more efficient critical organ sparing."

- Physics in Medicine and Biology

Table of Contents

PREFACE AND ACKNOWLEDGMENTS

INTENSITY-MODULATED RADIATION THERAPY (IMRT): GNERAL STATEMENTS AND POINTS OF DEBATE

Observations on IMRT at the current time

Criticism of the philosophy of IMRT

DEVELOPMENTS IN ROTATION IMRT AND TOMOTHERAPY

NOMOS MIMiC tomotherapy

University of Wisconsin machine for tomotherapy

Tomotherapy using a 60Co source

Tomotherapy with an MLC

Summary

DEVELOPMENTS IN IMRT USING A MULTILEAF COLLIMATOR (MLC)

New sequencers/interpreters

Radiation leakage and accounting for machine effects in IMRT delivery

Dose calculation for IMRT

Features of MLC delivery of IMRT

Dynamic arc therapy

Combining step-and-shoot and dynamic delivery for dMLC

IMAT-technical issues

New ideas related to the dMLC technique

Compensators and comparisons of compensator and MLC-based IMRT

Optimum width of leaves for an MLC

MicroMLCs for IMRT

Increasing the spatial resolution of a conventional MLC

Verification of MLC-delivered IMRT

Quality assurance (QA) of MLC delivery

Summary

DEVELOPMENTS IN IMRT NOT USING AN MLC

The Cyberknife

The design of the shuttling MLC (SMLC)

IMRT with the "jaws-plus-mask" technique

The variable aperture collimator (VAC)

One-dimensional IMRT

Summary

CLINICAL IMRT- EVIDENCE-BASED MEDICINE?

IMRT of the prostate showing measurable clinical benefit

Comparison of treatment techniques for the prostate

Royal Marsden NHS Foundation Trust pelvic and other IMRT

Comparison of IMRT with conformal radiotherapy (CFRT) for complex shaped tumors

IMRT for whole-pelvic and gynecological radiotherapy

Head-and-neck IMRT

Breast IMRT

Bladder IMRT at the Christie Hospital

Lung cancer IMRT

Scalp IMRT

Other clinical IMRT reports-various tumor sites

Summary

3D PLANNING FOR CFRT AND IMRT: DEVELOPMENTS IN IMAGING FOR PLANNING AND FOR ASSISTING THERAPY

Challenges to IMRT and inverse planning

Determination of the GTV, CTV, and PTV: the influence of 3D medical imaging

New inverse-planning methods for IMRT

New forward-planning methods for IMRT: direct aperture optimization

Smoothing IMBs

Incorporating MLC equipment constraints in inverse planning

Beam direction optimization

Monte Carlo dose calculation

Energy in IMRT

Measuring and accounting for patient/tumor movement

Megavoltage CT (MVCT) and kilovoltage CT (kVCT) for position verification

MRI and IMRT simultaneously

IMRT using mixed photons and electrons

EPILOGUE

REFERENCES

INDEX

About the Series

Series in Medical Physics and Biomedical Engineering

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Subject Categories

BISAC Subject Codes/Headings:
MED080000
MEDICAL / Radiology & Nuclear Medicine
SCI055000
SCIENCE / Physics