Controlled Release Dosage Form Design: 1st Edition (Hardback) book cover

Controlled Release Dosage Form Design

1st Edition

By Cherng-ju Kim

CRC Press

310 pages

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Hardback: 9781566768108
pub: 1999-10-25
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Controlled Release Dosage Form Design offers the tools needed to eliminate trial-and error and wasted time and money in controlled release dosage form design! How is this accomplished? By helping the reader UNDERSTAND controlled release technology more quantitatively and mechanistically, thereby creating a "visual" overall picture of the technology.

Controlled Release Dosage Form Design is an invaluable tool for all students and professionals in pharmaceutics, chemistry, chemical engineering, biology/biotechnology and medicine. If you are engaged or interested in the development of dosage forms, you will find this book invaluable. You will learn to look at controlled release dosage forms INTERRELATED to each other, rather than piece by piece. You will learn to KNOW how the mechanistic principles which can be applied in dosage forms. Work faster, smarter and with more intuition!

Table of Contents


Conventional vs. Controlled Release

Advantages and Disadvantages

Pharmacokinetic Considerations of CRDF

Polymers as Drug Carriers

Classification of CRDFs

Monolithic Matrix Controlled Systems

Dissolved Drugs

Dispersed Drugs

Drug-dissolution/diffusion Controlled Systems

Membrane Controlled Systems

Constant Activity Reservoir

Non-Constant Activity Reservoir

Release of a Drug from a Membrane Reservoir into a Finite Volume

Unsteady State Analysis (Time-lag & Burst-effect)

Drug Release from Multi-layer Membrane Devices

Drug Release from Membrane-matrix Systems

Membrane Transport with Bio-conversion

Swelling Controlled Systems

Mathematical Expression

Hydrogel Systems

Polymer Dissolution Controlled Systems

Classification of Polymer Degradation and Erosion

Heterogeneous Erosion

Homogeneous Erosion

Acid Catalyzed Degradation

Autocatalyzed Degradation

Erosion/Drug Diffusion Controlled

Swelling/Erosion Controlled

Preparation of Biodegradable Microparticles

Gradient Matrix Systems

Mathematical Expression


Hydrogel Beads



Ion Exchange Resin Systems

Exchange Process and Equilibrium

Ion Exchange Materials

Drug Release from Commercial Ion Exchange Resins

Highly Swellable Polyelectrolyte

Erodible Polyelectrolyte

Principle of Diffusion in the Ion Exchange Resin Matrix (Shrinking-core Model)

Drug Release in a Limited Volume

Osmotically Controlled Systems


Elementary Osmotic Pump (OROS)

Solubility Modulated OROS

Microporous Osmotic Pump


Geometrically Modified Systems

Pie Shape, Perforated Coated, Donut (Coated/Uncoated), and Multi-hole

Frustum and Hemisphere

Multi-layer Tablet and Cylinder Systems

Other Systems

Hydrodynamically Balanced Systems

Oral Time-controlled (Pulsatile) Release Systems

Pharmacokinetic Considerations of CRDF Design

One-compartment Model

Two-compartment Model with Zero-order Release Kinetics

Pharmacokinetics on Transdermal Delivery Systems

In-vitro/In-vivo Correlation

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology