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Controlled Release Dosage Form Design



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ISBN 9781566768108
Published October 25, 1999 by CRC Press
310 Pages

 
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Book Description

Controlled Release Dosage Form Design offers the tools needed to eliminate trial-and error and wasted time and money in controlled release dosage form design! How is this accomplished? By helping the reader UNDERSTAND controlled release technology more quantitatively and mechanistically, thereby creating a "visual" overall picture of the technology.

Controlled Release Dosage Form Design is an invaluable tool for all students and professionals in pharmaceutics, chemistry, chemical engineering, biology/biotechnology and medicine. If you are engaged or interested in the development of dosage forms, you will find this book invaluable. You will learn to look at controlled release dosage forms INTERRELATED to each other, rather than piece by piece. You will learn to KNOW how the mechanistic principles which can be applied in dosage forms. Work faster, smarter and with more intuition!

Table of Contents

Introduction
Conventional vs. Controlled Release
Advantages and Disadvantages
Pharmacokinetic Considerations of CRDF
Polymers as Drug Carriers
Classification of CRDFs
Monolithic Matrix Controlled Systems
Dissolved Drugs
Dispersed Drugs
Drug-dissolution/diffusion Controlled Systems
Membrane Controlled Systems
Constant Activity Reservoir
Non-Constant Activity Reservoir
Release of a Drug from a Membrane Reservoir into a Finite Volume
Unsteady State Analysis (Time-lag & Burst-effect)
Drug Release from Multi-layer Membrane Devices
Drug Release from Membrane-matrix Systems
Membrane Transport with Bio-conversion
Swelling Controlled Systems
Mathematical Expression
Hydrogel Systems
Polymer Dissolution Controlled Systems
Classification of Polymer Degradation and Erosion
Heterogeneous Erosion
Homogeneous Erosion
Acid Catalyzed Degradation
Autocatalyzed Degradation
Erosion/Drug Diffusion Controlled
Swelling/Erosion Controlled
Preparation of Biodegradable Microparticles
Gradient Matrix Systems
Mathematical Expression
Tablets
Hydrogel Beads
Granules
Megaporous
Ion Exchange Resin Systems
Exchange Process and Equilibrium
Ion Exchange Materials
Drug Release from Commercial Ion Exchange Resins
Highly Swellable Polyelectrolyte
Erodible Polyelectrolyte
Principle of Diffusion in the Ion Exchange Resin Matrix (Shrinking-core Model)
Drug Release in a Limited Volume
Osmotically Controlled Systems
Osmosis
Elementary Osmotic Pump (OROS)
Solubility Modulated OROS
Microporous Osmotic Pump
Push-Pull
Geometrically Modified Systems
Pie Shape, Perforated Coated, Donut (Coated/Uncoated), and Multi-hole
Frustum and Hemisphere
Multi-layer Tablet and Cylinder Systems
Other Systems
Hydrodynamically Balanced Systems
Oral Time-controlled (Pulsatile) Release Systems
Pharmacokinetic Considerations of CRDF Design
One-compartment Model
Two-compartment Model with Zero-order Release Kinetics
Pharmacokinetics on Transdermal Delivery Systems
In-vitro/In-vivo Correlation

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