287 pages | 22 Color Illus. | 108 B/W Illus.
Written by an interdisciplinary team of medical doctors, computer scientists, physicists, engineers, and mathematicians, Correction Techniques in Emission Tomography presents various correction methods used in emission tomography to generate and enhance images. It discusses the techniques from a computer science, mathematics, and physics viewpoint.
The book gives a comprehensive overview of correction techniques at different levels of the data processing workflow. It covers nuclear medicine imaging, hybrid emission tomography (PET-CT, SPECT-CT, PET-MRI, PET-ultrasound), and optical imaging (fluorescence molecular tomography). It illustrates basic principles as well as recent advances, such as model-based iterative algorithms and 4D methods. An important aspect of the book is on new and sophisticated motion correction techniques in PET imaging. These techniques enable high-resolution, high-quality images, leading to better imaging analysis and image-based diagnostics.
Reflecting state-of-the-art research, this volume explores the range of problems that occur in emission tomography. It looks at how the resulting images are affected and presents practical compensation methods to overcome the problems and improve the images.
It is refreshing to have a text on emission molecular imaging relevant to animals and human beings with an emphasis on those factors that detract from resolution and quantification. This book implicitly distinguishes between molecular imaging of emitters and molecular imaging provided by magnetic resonance techniques such as magnetic resonance spectroscopy, magnetic resonance imaging of hyperpolarized and other contrast agents, and other magnetic resonance methods wherein the response to the injected pattern of the radiofrequency field is measured. … In sum, this book shows how researchers have overcome limitations in emission tomography noted 40 years ago and have brought the methods to the goal of high spatial resolution and quantification. Most importantly, these advances have enabled clinically useful applications not available to other diagnostic methods.
—From the Foreword by Thomas F. Budinger, University of California, Berkeley, USA
"This is a fairly comprehensive survey of current and future applications of emission tomography and associated reconstruction, correction, and image post-processing methods, with an emphasis on quantitative preclinical and clinical molecular imaging research (mostly PET). An advanced book, it is one written primarily from a computational science perspective. This book would benefit most those scientists with at least basic prior knowledge of the underlying physics and applications of, as well as a research interest in, PET, SPECT, and hybrid molecular imaging."
—William D Erwin, MS, University of Texas MD Anderson Cancer Center, Houston, USA
Introduction, Klaus Schäfers
Principle of Emission Tomography
Need for Correction Techniques
Biomedical Applications of Emission Tomography, Michael Schäfers, Sven Hermann, Sonja Schäfers, Thomas Viel, Marilyn Law, and Andreas H. Jacobs
The role of imaging in biomedical research and applications
Functional and molecular imaging by emission tomography enables high sensitivity and spatial resolution
Biomedical applications of emission tomography depend on tracers
PET Image Reconstruction, Frank Wübbeling
CORRECTIONS TECHNIQUES IN PET AND SPECT
Basics of PET and SPECT Imaging, Ralph A. Bundschuh and Sibylle I. Ziegler
Corrections for Physical Factors, Florian Büther
Corrections for Scanner Related Factors, Marc Huismann
Positron emission tomography
Single photon emission computed tomography
Image Processing Techniques in Emission Tomography, Fabian Gigengack, Michael Fieseler, Daniel Tenbrinck, and Xiaoyi Jiang
Partial volume correction
Motion Correction in Emission Tomography, Mohammad Dawood
Motion correction on 3D PET data
Lucas/Kanade optical flow
Horn/Schunck optical flow
Bruhn optical flow
Correcting for motion
Mass conservation-based optical flow
Combined Correction and Reconstruction Methods, Martin Benning, Thomas Kösters, and Frederic Lamare
Combined reconstruction and motion correction
Combination of parameter identification and motion estimation
Introduction into Hybrid Tomographic Imaging, Hartwig Newiger
Combining PET and SPECT
The combination with MR
Combining ultrasound with PET and SPECT
MR-Based Attenuation Correction for PET/MR, Matthias Hofmann, Bernd Pichler, and Thomas Beyer
MR-AC for brain applications
Methods for torso imaging
Optical Imaging, Angelique Ale and Vasilis Ntziachristos
Fluorescence molecular tomography (FMT)
FMT and hybrid FMT systems
References appear at the end of each chapter.