Critical Care Management for Laboratory Mice and Rats  book cover
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Critical Care Management for Laboratory Mice and Rats




ISBN 9780849324994
Published October 3, 2013 by CRC Press
271 Pages 69 Color Illustrations

 
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Book Description

For critical care of laboratory rodents, there is a scarcity of sources for comprehensive, feasible, and response-oriented information on clinical interventions specific to spontaneous and induced models of disease. With the more complex cases that need critical care management, many treatment approaches to veterinary emergencies cannot be applied directly to the laboratory rodent. The first text of its kind devoted to the challenges of critical care management for laboratory rodents, Critical Care Management for Laboratory Mice and Rats provides a specialized resource for all veterinary, husbandry, technical, and research professionals who utilize rodent models for biomedical research.

The book covers the varied approaches to laboratory rodent patient care, health assessments, characteristics of specific disease models, monitoring and scoring of disease parameters, and humane interventions. Giving primary consideration to preservation of animal health and welfare, the text also considers how best to balance welfare with the achievement of proposed scientific objectives. Organized into five chapters, this full-color book covers the following topics:

  • General Approaches for Critical Care
  • Critical Care Management for Laboratory Mice
  • Critical Care Management for Laboratory Rats
  • Special Considerations for Critical Care Management in Laboratory Rodents
  • Resources and Additional Information

The author provides treatment guidelines with the expectation that they will be applied with apt professional judgment, allowing for further modification of clinical recommendations for improved patient-based care and welfare for research animals.

Table of Contents

general approaches for critical care
overview
obtaining a clinical history and medical records
body condition scoring
relocation for physical examinations
monitoring critically ill rodents
pain recognition and assessments
supportive care for surgical procedures
supplemental heat provision
drug therapy
references

critical care management for laboratory mice
introduction
overall assessments
general medical approaches to physical examination and health assessments
veterinary care measures
abnormal, critical, and emergent conditions
research-related medical issues
euthanasia
references

critical care management for laboratory rats
introduction
overall assessments
general medical approaches to physical examination and health assessments
veterinary care measures
abnormal, critical, and emergent conditions
research-related medical issues
euthanasia
references

special considerations for critical care management in laboratory rodents
introduction
aging animal model considerations
blood loss considerations
chronic indwelling device considerations
depilatory cream considerations
equipment considerations for rodent surgery
and emergency procedures
euthanasia considerations
experimental autoimmune encephalomyelitis and demyelinating disease model considerations
fasting considerations
fluid therapy considerations
food and fluid regulation procedures
humane or "clinical" endpoint considerations
nutritional therapy considerations
perioperative care considerations
regulatory considerations
restraint collar considerations
tracheostomy considerations
tumor development and monitoring considerations
wound management considerations
references

resources and additional information
introduction
organizations
publications
electronic resources
commercial resources

appendix A: glossary of acronyms and terms
appendix B: suggested medical supplies for rodent
critical care
appendix C: rodent formulary
Index

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Author(s)

Biography

F. Claire Hankenson, DVM, MS, is the senior associate director in University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, and is an associate professor of laboratory animal medicine in the Department of Pathobiology at the School of Veterinary Medicine. Dr. Hankenson obtained her veterinary degree from Purdue University. Following veterinary school, she completed her laboratory animal medicine residency and graduate work (MS, microbiology) at the University of Washington, Seattle. She became a Diplomate of the American College of Laboratory Animal Medicine (ACLAM) in 2002. Her own research studies involve investigations of refinements in the care and use of laboratory rodents, particularly blood sampling, tail biopsy evaluations, and humane endpoints.