Presents a state-of-the-art examination of Crohn's disease (CD), from an historical evolution of the field to future developments of etiopathogenesis, diagnostic evaluation, and therapeutic management. Reviews possible etiologic agents, the various ways CD progresses, novel diagnostic techniques, and standard and innovative therapies. Emphasizes the application of recent advances in basic research to clinical management of the disease.

    Introduction

    Conversation with Burrill B. Crohn, Leon Ginzburg, and Gordon Oppenheimer 63 Years after the Discovery of Crohn's Disease, Henry D. Janowitz
    Causes and Mechanisms, Jeffry A. Katz and Claudio Fiocchi
    Commentary, Derek Jewell
    Epidemiology of Crohn's Disease, Anders Ekbom
    Commentary, Robert S. Sandler
    Consideration of Smoking in Patients with Crohn's Disease, Bret A. Lashner

    Evaluation of the Patient

    Pathology and Pathophysiology of Symptoms, William J. Tremaine
    Commentary, Sidney F. Phillips
    Endoscopic Evaluation, Geert D'Haens and Paul Rutgeerts
    The Role of Contrast Barium X-Rays vs. Endoscopy, Burton I. Korelitz
    Commentary, Robert Modigliani
    Cross-Sectional Imaging in the Evaluation of Crohn's Disease, Richard M. Gore, Gary G. Ghahremani, and Frank H. Miller
    Commentary, Daniel Maklansky
    Proposed Measures of Disease Activity: How Useful Are They?, Cosimo Prantera and Anna Kohn
    Commentary, John W. Singleton
    Different Patterns of Crohn's Disease, Lloyd R. Sutherland
    Commentary, David B. Sachar

    General Therapeutic Approach

    Immunosuppressive Therapy of Crohn's Disease: A Historical Perspective, Burton I. Korelitz
    Treatment of Active Crohn's Disease with Salazopyrine and Derivatives of Aminosalicylic Acid (5-ASA), Cosimo Prantera, Maria Lia Scribano, and Eva Berto
    The Role of Steroids in the Management of Crohn's Disease, Burton I. Korelitz
    Clinical Picture of Crohn's Disease: Upper Gastrointestinal Tract, Adrian J. Greenstein and James Aisenberg
    Clinical Picture of Crohn's Disease: Lower Intestinal Tract, Norman Sohn
    Commentary, John Alexander-Williams

    Special Situations

    Prevention of Relapse and Recurrence, Cosimo Prantera and Arnaldo Andreoli, Commentary, David B. Sachar
    Nutrition and Special Diets, John E. Lennard-Jones
    Commentary, Arthur D. Heller
    Crohn's Disease in Childhood and Adolescence, Jay A. Barth and Richard J. Grand
    Commentary, Frederic Daum
    Crohn's Disease in the Elderly, Geetanjali A. Akerkar and Mark A. Peppercorn
    Commentary, Nadir Arber and Peter R. Holt
    Refractory Crohn's Disease, Stephen B. Hanauer
    Commentary, Theodore M. Bayless
    The Role of Antibiotics in Crohn's Disease, Peter S. Margolis and Walter R. Thayer, Jr.
    Commentary, Cosimo Prantera
    Pregnancy and Fertility in Crohn's Disease, Daniel H. Present
    Commentary, Robert Burakoff
    Psychosocial Issues in Crohn's Disease, Susan Levenstein
    Quality of Life Issues in Crohn's Disease, Douglas A. Drossman
    Commentary, Barbara S. Kirschner
    The Psychiatric Treatment of Patients with Crohn's Disease, Marvin Kaplan
    Commentary, Barbara S. Kirschner
    Extraintestinal Manifestations, Andrew S. Warner and Richard P. MacDermott
    Commentary The Systemic Nature of Inflammatory Bowel Disease, Lloyd Mayer
    Liver Complications, Harvey M. Lieberman
    Commentary, Nicholas F. LaRusso
    Malignancy in Crohn's Disease, Paul M. Choi
    Commentary, Burton I. Korelitz
    Ileal Pouch in Crohn's Disease, R. John Nicholls
    The Effects of Nonsteroidal Anti-Inflammatory Drugs on Crohn's Disease, Joseph B. Felder
    Commentary, Burton I. Korelitz
    Medical Therapy of Crohn's Disease: Obsolete or Unproven Approaches, Samuel Meyers
    The Experience of Crohn's Disease: Is the Bed Now a Table?, Howard M. Spiro
    The Future of Crohn's Disease: New Developments in Etiopathogenesis and Therapeutics, Maria T. Abreu and Stephan R. Targan

    Biography

    Prantera, Cosimo; Korelitz, Burton

    "
    Congratulations to Drs. Korelitz and Prantera…a state-of-the-art publication devoted to Crohn's disease with special focus on etiopathogenesis, diagnostic evaluation, and therapeutic management…
    …provides an up-to-date all-inclusive resource…highly recommend[ed]… a worthwhile purchase and deserves a place in your library.
    "-Gastroenterology

    The book considers every aspect of the disease"…
    …an excellent, unusually readable book.
    "-The New England Journal of Medicine