Current Concepts in Carnitine Research is based on the proceedings of a symposium on carnitine research presented by the School of Medicine, Medical College of Georgia, April 20-21, 1991. The book is intended to introduce areas of carnitine research and explore key clinical and basic aspects of carnitine metabolism. The four major topics covered are carnitine and the heart; the structure, function, and regulation of carnitine palmitoyl transferase; functions of the short chain carnitine acyltransferase; and areas of carnitine research. This information is essential for physicians and biochemists studying intermediate metabolism, nutritionists involved in dietary nanuplication, and cardiology researchers, especially those studying cardiomyopathy.
PART I: Introduction (A.Lee Carter, Ph.D.). Acyl Carnitine: Function and Enzymology (Loren L. Bieber, Ph.D.). Carnitine and Valproate (Timothy Bohan, M.D.). Biochemical Properties of Propionyl Carnitine and Isovaleryl-Carnitine (Noris Silliprandi, M.D., Ph.D.). Metabolic Fate of Dietary Carnitine in Humans (Charles J. Rebouche, Ph.D.). PART II: Introduction (A. Lee Carter, Ph.D.). Carnitine in Food Animal Production (G. Larry Newton, Ph.D.). Carnitine - Alcohol Interaction in Mammalian Systems (Dileep S. Sachan, Ph.D.). Designing Active-Site Probes of Carnitine Acyltransferases: Potentially Potent Regulators of Lipid Metabolism (Richard D. Gandour, Ph.D.). Sites of Action of Carnitine: An Overview (Irving B. Fitz, Ph.D.) PART III: Introduction (Loren L. Bieber, Ph.D.). Newer Insights into the Carnitine Palmitoyl Transferase Enzyme System (J. Dennis McGarry, Ph.D.). Carnitine Palmitoyl Transferase (Charles Hoppell, M.D.). Carnitine Palmitoyl Transferases: How Many and How to Discriminate (Shri V. Pande, Ph.D.). Clinical Deficiencies of CPT (J.M. Saudubray, M.D.). PART IV: Introduction (Ann Willbrand, Ph.D.). Carnitine and Myocardial Function (Mary Ella Pierpont, M.D.). Carnitine Deficiency and the Diabetic Heart (Dennis J. Paulson, Ph.D). Effects of Carnitine and Carnitine Acyltransferase Inhibition on Energy Substrate Utilization in the Intact Heart (Gary D. Lopaschuk, Ph.D.). Additional Areas of Carnitine Research (A. Lee Carter, Ph.D.).