Cyclic Nucleotide Signaling: 1st Edition (Hardback) book cover

Cyclic Nucleotide Signaling

1st Edition

Edited by Xiaodong Cheng

CRC Press

288 pages | 9 Color Illus. | 48 B/W Illus.

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Hardback: 9781482235562
pub: 2015-05-12
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pub: 2015-05-07
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Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.

Table of Contents

Compartmentalization of cyclic nucleotide signaling

Analysis of EPAC-mediated cAMP functions in cell communication

Cyclic nucleotide analogs as pharmacological tools for studying signaling pathways

Discovery of small molecule EPAC specific modulators

Adenylyl cyclase and A kinase-anchoring proteins in cardiovascular physiology and pathology

Cyclic nucleotide recognition and selectivity

Real-time intracellular imaging of cGMP

Dissecting cyclic nucleotide signalosomes by chemical proteomics

Cyclic nucleotide analogs as chemical tools for interaction analyses

cAMP signaling in pancreatic β cells

Quantitative high throughput cAMP assay for G-protein coupled receptors

Quantitative proteomics analysis of the cAMP signaling pathway

Network analysis of cyclic nucleotide signaling

Evolution and functional diversity of cyclic nucleotide binding domains

X-ray crystallographic analysis of cyclic nucleotide activated protein kinases

Dissect physiological functions of PKA isoforms using genetically modified mouse models

Assessing cyclic nucleotide binding domain allostery by NMR analysis

Fluorescence resonance energy transfer (FRET) imaging of cyclic nucleotide in live cells

Structural and functional analyses of exchange protein directly activated by cAMP

Structural analysis of PKA: strategies for therapeutic intervention

Monitoring cyclic nucleotide signaling using genetically encoded fluorescent reporters

About the Series

Methods in Signal Transduction Series

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Endocrinology & Metabolism
SCIENCE / Life Sciences / Cytology
SCIENCE / Life Sciences / Biology / Molecular Biology