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DNA Liquid-Crystalline Dispersions and Nanoconstructions





ISBN 9781439871461
Published September 2, 2011 by CRC Press
304 Pages 19 Color & 128 B/W Illustrations

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Book Description

The discovery of the spatial structure of the double-stranded DNA molecule is one of the greatest achievements of science. It would not be an exaggeration to say that the DNA double helix is a distinguished symbol of modern biology.

Divided into three parts, DNA Liquid-Crystalline Dispersions and Nanoconstructions covers the information presently available on the condensation of various forms of DNA and describes practical applications of the peculiar properties of the liquid-crystalline particles.

  • Part 1 describes the main methods used for condensation of linear high- and low-molecular mass DNA, including their complexes with polycations and circular DNA
  • Part 2 compares the state and reactivity of double-stranded nucleic acid molecules fixed spatially in the liquid-crystalline as well as the same molecules under intracellular conditions
  • Part 3 explains how the discovery of the fundamental principles underlying the formation of nucleic acid liquid-crystalline dispersion particles opens a gate for the operational use of these principles in the area of nanotechnology and biosensorics


With detailed coverage of DNA liquid crystals, this book provides an understanding of the information presently available on the condensation of various forms of DNA. Double-stranded nucleic acids, spatially organized in a liquid-crystalline structure, represent an important polyfunctional tool for molecular biology and nanobiotechnology. The possibility of programmed and controlled variations in the properties of these molecules and in the characteristics of their liquid-crystalline dispersions, provides wide options for the formation of biologically active three-dimensional structures with unique, widely applicable properties.

Table of Contents

The Liquid-Crystalline State of DNA: Condensed state of high molecular mass DNA. Liquid-crystalline phases of low-molecular mass double-stranded DNA. Dispersions of low molecular mass double-stranded DNA. Circular dichroism of nucleic acids dispersions. Polymorphism of liquid-crystalline structures formed by interaction of DNA with polycations. Liquid-crystalline state of circular DNA. Conclusion. The Liquid-Crystalline Forms of DNA Under Endocellular Conditions and Biological Potency of DNA: Liquid-crystalline state of DNA in biological systems. DNA reactions under conditions ensuring formation of liquid-crystalline dispersions. Conclusion. DNA Liquid-Crystalline Dispersions in Nanotechnology and Biosensorics: Nanostructures based on nucleic acids. Biosensors based on nucleic acids. Conclusion.

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Author(s)

Biography

Yevdokimov Yuri Mikhailovich - Dr. Sci. (Chemistry), Professor: Head of the Condensed State of Nucleic Acids laboratory at Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences.
Interests: chemistry of natural and physiologically relevant compounds (especially, nucleic acids), lyotropic liquid crystals of biopolymers, biosensors, and nanotechnology of nucleic acids.

Salyanov Victor Ivanovich - Ph.D. (Chemistry): Senior research scientist of the Condensed State of Nucleic Acids laboratory at Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences.
Interests: chemistry of natural and physiologically relevant compounds, lyotropic liquid crystals of nucleic acids, and nanotechnology of nucleic acids.

Semenov Sergey Victorovich - Ph.D. (Physics): Senior research scientist at the Russian Research Center’s Kurchatov Institute
Interests: physics of liquid crystals, elementary particles physics and interaction of radiation with matter

Skuridin Sergey Gennadievich - Dr. Sci. (Molecular Biology): Leading research scientist of the Condensed State of Nucleic Acids laboratory at Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences.
Interests: biochemistry of natural and physiologically relevant compounds, lyotropic liquid crystals of nucleic acids, biosensors, and nanotechnology of nucleic acids.