Deferred Development: Setting Aside Cells for Future Use in Development in Evolution, 1st Edition (Hardback) book cover

Deferred Development

Setting Aside Cells for Future Use in Development in Evolution, 1st Edition

Edited by Cory Douglas Bishop, Brian K. Hall

CRC Press

328 pages | 20 Color Illus. | 30 B/W Illus.

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Hardback: 9781138334281
pub: 2019-11-26
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This volume examines cells set-aside during development for use later in ontogeny or in adult life. There is no single term for such cells. The cells explored fall with several major categories — stem cells, set-aside cells (in echinoderm larvae), imaginal discs in insects such as Drosophila, meristems (plants), blastemata (regeneration in amphibians), neoblasts (regeneration in planarians). The book compares and contrasts these cells types and the environments (niches) in which they operate with the aim of unravelling any relationships between them, between their activation in development, and in their evolution.

Key Features

  • Explores the nature of deferred-use cells in evolutionary and developmental context.
  • Reviews the mechanisms of development of set-aside cells, such as stem cells, meristems, and imaginal discs.
  • Provides phylogenetic overview of different types of deferred-use cells.
  • Compares and contrasts different theories on the origin of deferred-use cells.

Related Titles

Calegari, F. & C. Waskow, eds. Stem Cells: From Basic Research to Therapy (ISBN 978-1-4822-0775-0)

Cabral, J. M. S. & C. L. da Silva, eds. Bioreactors for Stem Cell Expansion and Differentiation (ISBN 978-1-4987-9590-6)

Table of Contents

Section I Deferred-use Cells in Development and Evolution. Deferred-use cells/niches: Evolutionary -life history perspective chapter. Deferred-use cells/niches: Developmental mechanisms chapter. Section II Phylogenetic overview of types of deferred-use cells and their niches. Stem cells and stem cell niches in animals: Classic example of life long multipotential cells. Deferred-use cells and niches in Fungi, lichens, mosses. Meristems and niche in plants. Set-aside cells (juvenile rudiments) and their niches in echinoderms. multipotential cells in embryos/larvae with metamorphosis. Imaginal disc cells and their niches in insects (Drosophila): Determined cells specified for individual parts of the adult body. Blastemal cells and neoblasts in amphibian and planarian regeneration. Section III Origin and evolution of deferred-use cells. Deferred-use cells in non-bilaterian animals (cnidarians, ctenophores) and in choanoflagellates and the evolutionary origin of deferred-use cells in animals. Deferred-use cells and the evolution of complexity, complex life cycles, direct/indirect development and response of deferred-use cells to selection. Deferred-use cells, germ cells and gametes, separation of germ line and soma. Deferred-use cells, and the evolution of phenotypic plasticity, life history stages and control of body size. Section IV Mechanisms of maintenance/activation of deferred-use cells during ontogeny. The role of cell cycle/mitosis in the evolution of deferred-use cells. Deferred-use cells and regulation of cell differentiation, de- and redifferentiation. Cancer and stem-cell related diseases as the cost of having deferred-use cells. Genetic and epigenetic control of deferred-use cells and their niches: Hippo pathway and mechanical factors in imaginal discs as major examples but with comparisons among model systems. Hormonal and metabolic regulation of maintenance/activation of deferreduse cells and their niches. Section V Overview and Future prospects. Overview and summary of the cells and niches, molecular control, phylogenetic history and evolution.

About the Editors

Cory Bishop is an Assistant Professor in the Departmetn of Biology at St. Francis-Xavier University. He received his PhD from Simon Fraser Univeristy in Vancouver, British Columbia, Canada. He has authored or co-authred over 20 peer reviewed scholarly journal articles.

Brian K. Hall FRSC (born, 1941) is the George S. Campbell Professor of Biology and University Research Professor Emeritus at Dalhousie University in Halifax, Nova Scotia. Professor Hall has researched and extensively written on bone and cartilage formation in developing vertebrate embryos. He is an active participant in the evolutionary developmental biology (EVO-DEVO) debate on the nature and mechanisms of animal body plan formation. Professor Hall has proposed that the neural crest tissue of vertebrates may be viewed as a fourth embryonic germ layer. As such, the neural crest - in Hall's view - plays a role equivalent to that of the endoderm, mesoderm, and ectoderm of bilaterian development and is a definitive feature of vertebrates (as hypothesized by Gans and Northcutt[1983]). As such, vertebrates are the only quadroblastic, rather than triploblastic bilaterian animals. In vertebrates the neural crest serves to integrate the somatic division (derived from ectoderm and mesoderm) and visceral division (derived from endoderm and mesoderm) together via a wide range novel vertebrate tissues (bone, cartilage, sympathetic nervous system, etc…). He has been associated with Dalhousie University since 1968. Since his retirement in 2007, he has been University Research Professor Emeritus and Emeritus Professor of Biology. (this taken from

About the Series

Evolutionary Cell Biology

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Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Life Sciences / General