Dendrimers, hyperbranched macromolecules, emerged just few decades ago but show promising potential as drug delivery nanocarriers, theranostic agents and gene vectors; in the pharmaceutical research and innovation area as well as in other healthcare applications. Although tremendous advancements have been made in dendrimer chemistry and their applications since their emergence, the synthesis, development and design of pure and safe dendrimer-based products have been a major challenge in this area.
This book, edited by well-known researchers in the area of nanomaterials and drug-based drug delivery applications, exhaustively covers the nanotechnological aspects, concepts, properties, characterisation, application, biofate and regulatory aspects of dendrimers. It includes sixteen vivid chapters by renowned formulators, researchers and academicians from all over the world, highlighting their specialised areas of interest in the fields of chemistry, biology, pharmacy and nanomedicine.
• Highlights dendrimers’ advancements in nanomedicine in the development of safe healthcare and biotechnological products
• Covers physicochemical aspects, biofate, drug delivery aspects and gene therapy using dendrimers
• Covers biomedical application of dendrimers in the field of biological sciences
• Gives examples of dendrimer–guest interaction chemistry
Dendrimers in Nanomedicine: Concept, Theory and Regulatory Perspectives provides the comprehensive overview of the latest research efforts in designing, optimising, development and scale-up of dendrimer-mediated delivery systems. It analyses the key challenges of synthesis, design, molecular modelling, fundamental concepts, drug delivery aspects, analytical tools and biological fate as well as regulatory consideration to the practical use of dendrimer application.
Dr. Neelesh Kumar Mehra Assistant Professor of Pharmaceutics in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, India. He has authored more than sixty peer-reviewed publications in highly reputed international journals, as well as book chapters and contributions on two patents. Dr. Mehra has 11 years of rich research and teaching experience in the formulation and development of complex, innovative biopharmaceutical products including micro- and nanotechnologies for regulated markets.
Dr. Keerti Jain Assistant Professor of Pharmaceutics in the Department of Pharmaceutics, NIPER, Raebareli, India. For more than 10 years, she has been actively engaged in formulation and development of nanomedicines. Dr. Jain has supervised masters and doctoral pharmaceutics students in their research works which have been published in high quality, good impact factor journals. She has also authored more than 60 international manuscripts in peer reviewed high impact journals. In 2019, she was awarded the prestigious ICMR-Amir Shakuntala Award.
Table of Contents
Nanotechnology: Introduction and Basic Concepts
Brijesh Ojha, Vineet Kumar Jain, Neelesh Kumar Mehra, Keerti Jain
Fundamental aspects of Targeted Drug Delivery
Javed Ahmed Ameeduzzafar, Nabil K Alruwaili, Syed Sarim Imam, Muhammad Afzal, Khalid Saad Alharbi, Md. Rizwanullah, Javed Ahmad
Dendrimers Nanomedicine: History, concept and properties of dendrimers
Classification and Type of dendrimers, Introduction and Chemistry
Anjali Rajora, Kalpana Nagpal
Macromolecular architecture and Molecular modelling of dendrimers
Rahul Gauro,Keerti Jain, Vineet Kumar Jain, Neelesh Kumar Mehra, Harvinder Popli
Synthesis of the Dendrimers
Abha Sharma, Ashima Thakur
Functionalization of the Dendrimers
Divya Bharti Rai, Deep Pooja, Hitesh Kulhari
Characterization of dendrimers: methods and tools
Sreejan Manna, Sougata Jana
Dendrimers-ghost interaction chemistry
Valamla Bhavana, Neelesh Kumar Mehra and Keerti Jain
Dendrimers in gene delivery
Dnyaneshwar Baswar, Ankita Devi, Awanish Mishra
Dendrimers in Diagnostics Application
Biplab Sikdar, Gagandeep Maan, Sri Madhuri S, Awanish Mishra
Dendrimers-nanomaterials conjugation: Concept, chemistry and application
Sonali Batra, Samridhi Thakral, Amit Singh and Sumit Sharma
Smart functionalized dendrimeric medicine in cancer therapy
Vijay Mishra, Manvendra Singh, Pallavi Nayak
Drug Delivery potential of Dendrimeric formulation
Musarrat Husain Warsi, Abdul Muheem, Abuzer Ali, Mohammad Yusuf, Mohammad Akhlaquer Rahan, Saima Amin, Javed Ahmad
Biomedical applications of Dendrimers
Sonali Batra and Sumit Sharma
Biofate, toxicity and regulatory consideration of dendrimers
Anisha D’Souza and Pratik Kumar Patel
Dr. Neelesh Kumar Mehra is working as Assistant Professor of Pharmaceutics, at Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, India. He earned his PhD with Prof. N.K. Jain from Dr. H.S. Gour University, Sagar and PostDoc from Texas A & M Health Science Centre, Kingsville, TX, USA. He served as Manager in Product Development, Sentiss Pharma Pvt Ltd. Gurgaon for development, scale-up and technology transfer of complex ophthalmic, inhalation, and otic pharmaceutical products. He received "TEAM AWARD" for successfully commercialization of Ophthalmic Suspension product. He is as an Editorial member of "Drug Delivery Letters" Journal, Bentham sciences. He has authored more than 50 peer-reviewed publications in high repute International Journals, 07 book chapters contributions. He guided PhD and M.S. students for their dissertations/research projects. He has received numerous outstanding awards including Young Scientist, Team Awards for their research output. He is peer reviewer of various international Journals and publishers. Currently he is editing books on Biopharmaceutical and nanotechnology based with CRC Press and Elsevier Pvt Ltd. He has 11 years rich research and teaching experience in the formulation and development of complex, innovative ophthalmic and injectable biopharmaceutical products including micro- and nano-technologies for regulated market and so on.
Dr. Keerti Jain earned her M. Pharm. and doctorate degree from Dr. H. S. Gour Central University, Sagar. She did her Post Doctorate from M. S. University of Vadodara, India as SERB-National Post-Doctoral Fellow. She has more 10 years of research experienced on Nanomedicine based drug delivery systems. Currently, she is efficiently fulfilling her responsibilities as Asst. Prof. and Scientists at Department of Pharmaceutics, NIPER, Rae Bareli, Lucknow, UP INDIA. Dr. Jain has supervised M. Pharm. and Pharm. D. students for their research works which have been published in quality journals with good impact factor. She is author of more than 60 international manuscripts in peer reviewed-high impact journals, including publications in Progress in Polymer Science having impact factor: 26.932, in biomaterials, drug discovery today, nanomedicine Current Opinion in Pharmacology, Antimicrobial agents and chemotherapy and other high impact factors. Her review articles entitled "Dendrimer Toxicity: Let’s Meet the Challenge" and "Dendrimers as Nanocarriers in Drug Delivery" published in International Journal of Pharmaceutics (2010) and Progress in Polymer Science (2014) was listed in top 25 articles. She has been author of 10 books and book chapters with international publishers. She has been awarded with research fellowships including SERB – Post Doctorate Fellowship, Senior research fellowship (CSIR), Junior research fellowship (UGC), Fellowship for training of young scientist (MPCST), Travel grant award (INSA) and International Travel Fellowship (ICMR and DBT) apart from several other prestigious grants, fellowships and awards. She has been nominated for Ranbaxy Research Scholar Award – 2012 and BioAsia Innovation Award – 2015. She has also been awarded with many best research presentation award in international conferences like NIPiCON-2014, International Science Congress-2012, APTI – Jaipur – 2018, SPER-Bangkok – 2019 and so on. She has been recipient of Pharmaceutical Science Alumni Award-2006 at Dr. H. S. Gour University, Sagar (M.P.). Till date she has been invited to present her research work at several national and seven international conferences including ICYRAM-2012 held at Singapore, Bioencapsulation – 2016 held at Lisbon, Portugal and International Conference – 2019 held at Bangkok. She won most innovative Idea award in LUFTHANSA impact week, which is a Reputed international platform.