1st Edition

Dermal Absorption and Toxicity Assessment and Dermatologic, Cosmeceutic, and Cosmetic Development: Therapeutic and Novel Approaches, 2 Volume Set

    1248 Pages
    by CRC Press

    This is a 2 volume set. Volume 1 is Dermatological and Cosmeceutical Development: Absorption Efficacy and Toxicity. Recent advances in our understanding of the development and morphology of normal skin has led to improved methods to deliver therapeutic compounds to selected targeted areas both within the skin and systemically. This reference provides a clear overview of current pharmaceutical and cosmetic practices in the management of both major and minor skin disorders, and provides an expansive overview of novel drugs and therapies used to treat these conditions. Written for scientists interested in dermatological therapy and those concerned with the marketing for pharmaceutical and cosmetic products, this text will also prove useful for students developing strong research methods. Volume 2 is Dermal Absorption and Toxicity Assessment, Second Edition The book Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin absorption and the various governmental and industrial programs concerned with skin permeation and toxicity. These include alternative in silico, in vitro, and in vivo strategies to conduct studies for regulatory requirements. To make room for this new expanded content, the editors are publishing a concurrent text entitled: Dermatological and Cosmetic Development with a concentration on subjects concerned with dermatological and cosmetic therapies. Dermal Absorption and Toxicity and Assessment is a completely revised and updated text expanded to include coverage pertaining to innovative research…expands on the specific barrier properties of the skin such as its physical structure, biosensor properties, cutaneous metabolism, skin lipid morphology, and dermal blood and lymphatic flow, examines both the standard established laboratory techniques, for example, diffusion cell technology, and also covers new techniques like cultured skin equivalents, dermal absorption, and risk assessment

    Volume 1 Skin structure, pharmaceutics, cosmetics, efficacy and toxicology of topically applied agents. Drugs used for skin diseases. Treatment of dermatitis. Evolution of cosmeceuticals and their application to skin disorders, including aging and blemishes. Biology of skin pigmentation and cosmetic skin color control. Evidence based cosmeceutical therapy. Skin Hydration - a key determinant in topical absorption. Epidemiology of skin barrier function: host and environment factors. Permeability through diseased and damaged skin. Targeting the pilosebaceous gland. Drug penetration enhancement through human nail and skin. Getting the dose right in dermatological therapy. Drugs for pain and inflammation. Novel topically active anti-inflammatory and anti-microbial compounds for use in acne. Codrugs: potential therapies for dermatological diseases. Topical therapeutic agents used in wound care. Established and Emerging Oral Antifungals in Dermatology. Hydroxy acids and retinoids in cosmetic products. Natural ingredients used in cosmeceuticals. The influence of formulation design on the clinical performance of topically applied formulations. Dry skin and moisturizers. Antioxidants in the skin: dermatological and cosmeceutical aspects. Absorption and evaporation of volatile compounds applied to skin. Efficacy, absorption and safety of essential oils. Sunscreens: efficacy, skin penetration and toxicological aspects. Efficacy and safety of Tea Tree and other oils. Safety assessments based on exposure, penetration and toxicity considerations. Non-invasive evaluation of skin in the cosmetic industry. Application of in vivo laser scanning microscopy for skin analysis in dermatology and cosmetology. Chemical penetration enhancement: possibilities and problems. Multicomponent formulations of chemical penetration enhancers. Iontophoresis. DNA transfer in the skin. Pressure waves for transdermal drug delivery. Microneedle arrays as transcutaneous delivery devices. Needle-free ballistic delivery of powdered immunotherapeutics to the skin using supersonic gas flow. Volume Human Skin Morphology and Dermal Absorption. Animal Skin Morphology and Dermal Absorption. SKIN BARRIER PROPERTIES AND ABSORPTION. The Physical Structure of the Skin Barrier. Skin Lipid Morphology and Function. Stratum Corneum as a Biosensor ;. Cutaneous Metabolism. Formulation Issues. MEASUREMENT OF SKIN ABSORPTION. Interpretation of In Vitro Skin Absorption Studies of Lipophilic Chemicals. Use of Skin Equivalents for Dermal Absorption and Toxicity. Skin Absorption as Studied by Spectroscopic Methods. MODELING OF DERMAL ABSORPTION AND RISK ASSESSMENT. Physiologically Based Pharmacokinetics and Pharmacodynamics of Skin. Beyond Stratum Corneum. Biophysical Models for Skin Transport and Absorption. Mathematical Models for Different Exposure Conditions.Modelling Skin Permeability in Risk Assessment. In Vitro-In Vivo Correlations in Transdermal Drug Delivery. Estimation of Subsequent Systemic Exposure - Physiological Models. "Riskofderm" - Predictions Based on In Vivo Factors. SKIN TOXICITY AND PREVENTION Quantitative Structure Activity Relationships for Skin Corrosivity and Toxicity Allergic Contact Dermatitis. Irritancy of Topical Chemicals and Transdermal Delivery Systems. Phototoxicity, Photocarcinogenicity and Photogenicity Systemic Toxicity in Man Secondary to Percutaneous Absorption. Effects of Solvents and Other Vehicles on the Stratum Corneum and Other Skin Components. REGULATORY ISSUES. Dermal Absorption of Chemicals: Some Australian Regulatory Considerations. International Perspectives in Dermal Absorption.Structure-Activity Relationships and Prediction of Photoallergic and Phototoxic Potential. Potential Regulatory Use of (Q)SARs to Develop Dermal Irritation and Corrosion Assessment Strategies. Development of (Q)SARs for Dermal Irritation and Corrosion Assessment Using EU New Chemicals Notification Data. Regulatory Assessment of Skin Sensitization. Assessment of Topical Bioequivalence Using Microdialysis and Other Techniques An Industry Perspective of Topical Dermal Bioequivalence. SPECIFIC EXAMPLES OF ABSORPTION Dermal Absorption of Chemical Contaminants from Soil. Percutaneous Absorption of Pesticides.Bathing Water: Percutaneous Absorption of Water Contaminants. Percutaneous Absorption of Pro- and Soft- Drugs. Skin Penetration of Cosmetic Ingredients and Contaminants. Percutaneous Absorption of Hair Dyes. Percutaneous Absorption of Fragrance Materials


    Michael S. Roberts (University of Queensland, Woolloongabba, Australia) (Edited by) , Kenneth A. Walters (An-eX Analytical Services Ltd., Cardiff, England, UK) (Edited by)