Chapman and Hall/CRC
Design Principles and Analysis Techniques for HRQoL Clinical TrialsSAS, R, and SPSS examples realistically show how to implement methods Focusing on longitudinal studies, Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition addresses design and analysis aspects in enough detail so that readers can apply statistical meth
Introduction and Examples. Study Design and Protocol Development. Models for Longitudinal Studies I. Models for Longitudinal Studies II. Moderation and Mediation. Characterization of Missing Data. Analysis of Studies with Missing Data. Simple Imputation. Multiple Imputation. Pattern Mixture and Other Mixture Models. Random Effects Dependent Dropout. Selection Models. Multiple Endpoints. Composite Endpoints and Summary Measures. Quality Adjusted Life-Years (QALYs) and Q-TWiST. Analysis Plans and Reporting Results. Appendices. References.