Design and Targeted Reactions of Oligonucleotide Derivatives: 1st Edition (Hardback) book cover

Design and Targeted Reactions of Oligonucleotide Derivatives

1st Edition

By Dmitri G. Knorre, Valentin V. Vlassov, Valentina F. Zarytova, Alexander V. Lebedev

CRC Press

384 pages

Purchasing Options:$ = USD
Hardback: 9780367246037
pub: 2019-06-18
$199.00
x

FREE Standard Shipping!

Description

First published in 1994, antisense oligonucleotides represent a new paradigm for drug delivery, employing a new class of chemicals to intervene in biological processes that have never before been used as sites for drug action. This book places antisense oligonucleotides in the context of drug discovery and development, reviewing the current status of research in antisense drugs and discussing strategies for future challenges and opportunities. It presents several antisense approaches, emphasizing the preparation, investigation, and applications of the reactive derivatives of antisense oligonucleotides. Specific topics covered include reagents able to modify nucleic acids, the methods for preparing these regeants, the reactions within the complexes with the target nucleic acids or oligonucleotides, and possible structural and kinetic problems. Biological applications of reactive oligonucleotide derivatives are considered as well.

Table of Contents

Compounds Capable of the Sequence-Specific Interaction with Nucleic Acids. Chemical Modification of Nucleic Acids. Synthesis of Oligonucleotide Derivatives. Sequence-Specific Chemical Modification of Nucleic Acids with Reactive Oligonucleotide Derivatives. Interaction of Oligonucleotide Derivatives with Nucleic Acids: Physicochemical Aspects. Oligonucleotide Derivatives as Biologically Active Compounds. References. Index.

About the Author

Dmitri G. Knorre, Valentin V. Vlassov, Valentina F. Zarytova, Alexander V. Lebedev, Olga S. Federova

About the Series

Routledge Revivals

Are there elusive titles that you need and have been trying to source for years but thought that you would never be able to find?

Well this may be the end of your quest – here is a fantastic opportunity for you to discover past brilliance and purchase previously out of print and unavailable titles by some of the world’s most eminent academic scholars.

Drawing from over 100 years of innovative, cutting-edge publishing, Routledge Revivals is an exciting programme whereby key titles from the distinguished and extensive backlist of the many acclaimed imprints associated with Routledge will be re-issued.

The programme draws upon the illustrious backlists of Kegan Paul, Trench & Trubner, Routledge & Kegan Paul, Methuen, Allen & Unwin and Routledge itself.

Routledge Revivals spans the whole of the Humanities and Social Sciences, and includes works by some of the world’s greatest thinkers including Emile Durkheim, Max Weber, Simone Weil, Martin Buber, Karl Jaspers and Max Beloff.

If you are interested in Revivals in the Behavioral Sciences, please visit https://www.routledge.com/series/PSYREVIVALS

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
MED071000
MEDICAL / Pharmacology