Designer Vaccines: Principles for Successful Prophylaxis seeks answers to these important questions and explores how immunological knowledge can be applied in the formulation and delivery of vaccines. Instead of focusing on the rating of existing vaccines, this forward-thinking text looks to how new vaccines can be developed and existing ones improved upon. The book provides sound immunological theory and fact as a basis for solving vaccine design problems.
Beginning with a discussion of disease and immunity to infection, Designer Vaccines: Principles for Successful Prophylaxis describes how events leading to immunity following infection must be considered in the rational design of vaccines. It also introduces the mucosal immune system and considers the special requirements of oral vaccines. Both viral and bacterial vectors for vaccine delivery are reviewed in detail.
Table of Contents
Immune Memory and Pathogenesis: The Promise and Limits of Vaccination, M. Campos
T-Cell Costimulation and Vaccination Design, Y. Liu
B-Cell Costimulation and Vaccine Development, D.M. Estes
Theoretical Basis of Cytokine Use with Vaccines, N.A. Mitchison and B. Muller
Cytokine Adjuvants: Lessons from the Past and Guidelines for the Future, H.P.A. Hughes
Mucosal Vaccine Designs for Enteric Infectious Agents, D. Pascual, H. Kiyono, and J.R. McGhee
Viral Vectors for Viral Vaccine Delivery, M. Sheppard and M. Boursnell
Bacterial Vectors for Vaccine Delivery, K. Jones
"This book provides a concise and very helpful overview of important considerations for the development of tomorrow's vaccines. Although the subject area is vast, the editors and authors have succeeded in compiling fundamental information essential to the development of protective vaccines. The book definitely represents an important addition to health science libraries as well as a helpful reference for vaccinologlists."
-Gregg N. Milligan, Children's Hospital Medical Center, in Doody's Weekly E-Mail Bulletin
"…this book offers excellent information on immune mechanisms in order to design safer and more efficient vaccines for future use in human health and we highly recommend the book for scientists and students who are dealing with vaccine delivery."
--Filiz Oner and A. Atilla Hincal, Journal of Controlled Release 58