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Development and Application of Biomarkers





ISBN 9781138114050
Published June 7, 2017 by CRC Press
297 Pages - 9 B/W Illustrations

 
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Book Description

First introduced to biomedical research in 1980, the term biomarker has taken on a life of its own in recent years and has come to mean a number of things. In biomedical science, biomarker has evolved to most commonly mean a characteristic that can be used either as a diagnostic or a prognostic, but most significantly as a screening indicator for pathologies that tend to be somewhat silent prior to overt clinical display.

Applying scientific rigor, as well as a disciplined approach to nomenclature, Roger Lundblad’s Development and Application of Biomarkers rationalizes the current enthusiasm for biomarkers with the use of well-established clinical laboratory analytes in clinical medicine. Highly respected for his work as both a classical protein scientist and as a pioneer in proteomics, Dr. Lundblad catalogs various biomarkers recognized in clinical medicine and, where possible, matches the expectations for advances in screening technologies with the realities of statistical analysis. More specifically, this important reference:

  • Details an extensive list of biomarkers for various stages of a number of cancer types including ovarian, pancreatic, prostate, and breast cancer
  • Looks at how proteomics is used for the discovery and validation of biomarkers
  • Explores the use of microarray technology, ultra-high performance liquid chromatography, and computational bioinformatic approaches for the discovery and use of biomarkers
  • Examines the use of cells and cell fragments as more complex biomarkers
  • Organizes a host of significant biomarkers and essential research by type and use in a series of readily accessible tables

Throughout this volume, Dr. Lundblad encourages consideration of biomarkers more as a concept than as laboratory analytes, emphasizing the relation between the discovery of a biomarker and the biology underlying its production. Ultimately, it is a thorough understanding of that underlying biology that will lead to the development of assays that are robust and reproducible, as well as clinically significant.

Table of Contents

Introduction to Biomarkers
Application of Biomarkers in Diagnostics, Prognostics, Theranostics, and Personalized Medicine
Introduction
Nomenclature/Definitions
Biomarkers and Diagnostics
Biomarkers and Screening
Biomarkers and Prognosis
Biomarkers and Theranostics and Personalized Medicine
Biomarkers and Specific Pathologies
Rheumatoid Arthritis
Inflammation Biomarkers in Different Pathologies
Biomarkers in Ophthalmology
Biomarkers in Neurology
Cardiac Biomarkers
Biomarkers in Renal Disease
Biomarkers for Bone
Biomarkers for Exposure to Environmental Toxins
Biomarkers and the Development of Biopharmaceuticals
Development of Biomarkers for Oncology
Intermediate Biomarkers and the Precancerous Condition
Cancer and Inflammation
Head and Neck Cancer
Ovarian Cancer
Pancreatic Cancer
Prostate Cancer
Breast Cancer
The Use of Proteomics to Discover Biomarkers
Blood
Urine
Saliva
Miscellaneous Biological Fluids/Excretory Products as Sources of Biomarkers
Biomarkers in Tissue Samples
Modified Proteins, Oligosaccharides, and Oligonucleotidesas Biomarkers
Complex Biomarkers: Cells, Cell Membrane Proteins, and Cell Fragments as Biomarkers
Use of Microarray Technology in Biomarker Discovery and Development
Development of Assays for Biomarkers
Appendix A: Model Standard Operating Procedure for an Assay

references provided at the end of every chapter

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Author(s)

Biography

Roger L. Lundblad is a highly accomplished expert in protein science and proteomics. He is well known for the rigorous application of classical protein science to more modern approaches and the development of a wealth of viable and practical applications. Dr. Lundblad is a native of San Francisco, California. He received his undergraduate education at Pacific Lutheran University and his Ph.D. degree in biochemistry at the University of Washington. After post-doctoral work in the laboratories of Stanford Moore and William Stein at the Rockefeller University, he joined the faculty of the University of North Carolina at Chapel Hill in 1968 attaining the rank of Full Professor in 1976 He joined the Hyland Division of Baxter Healthcare in 1990.

Currently Dr. Lundblad is an independent consultant and writer in biotechnology in Chapel Hill, North Carolina. He is an adjunct Professor of Pathology at the University of North Carolina at Chapel Hill and Editor-in-Chief of the Internet Journal of Genomics and Proteomics. He has authored and edited numerous books that focus both on advances in proteomics and modern applications as well as on the fundamentals of protein science. He recently co-edited Handbook of Biochemistry and Molecular Biology, Fourth Edition.