Development of Biopharmaceutical Parenteral Dosage Forms: 1st Edition (Hardback) book cover

Development of Biopharmaceutical Parenteral Dosage Forms

1st Edition

Edited by Cosimo Prantera, Burton I. Korelitz

CRC Press

264 pages

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Hardback: 9780824799816
pub: 1997-07-25
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pub: 1997-07-25
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Description

This up-to-the-minute reference delineates-in a systematic fashion-the appropriate, sequential steps for the formulation of safe, effective, stable, and marketable liquid parenteral biopharmaceutical products-covering fundamentals and essential pathways for each phase as well as its purpose, function, and relation to other stages in the product development process.

Written by experts currently involved in state-of-the-art advances in the pharmaceutical drug industry, Development of Biopharmaceutical Parenteral Dosage Forms

  • details biopharmaceuticals that are licensed or undergoing clinical development, including genetically engineered cell and engineered vectors in the fermentation process

  • describes purification and characterization techniques for rDNA therapeutics, discussing several types of unit operations for isolation, purification, and characterization

  • considers preformulation and formulation requirements, such as physicochemical properties, drug delivery, stability studies programs, deactivation/denaturation routes, selection of compatible excipients, and regulatory compliance

  • elucidates basics of analytical techniques, methods development, separation methods using chromatographic and electrophoretic techniques, and bioactivity methods covering bioassays and immunoassays for quantifying the stability of biological activity

  • shows how to select the appropriate filter for maximizing compatibility and minimizing adsorption and inactivation, examining topics from basic filtration theories to future trends

  • reviews the selection process for compatible elastomeric closures, analyzing physical, chemical, toxicological properties, protein adsorption on elastomeric surfaces, strategies to reduce/eliminate adsorption, and specialized containers for biotechnological applications

  • and more!

    Furnished with helpful references, tables, and drawings, this practical guide is indispensable for pharmaceutical, medicinal, and protein chemists; molecular biologists; process engineers; purification scientists; biopharmaceutical and pharmaceutical formulators and product developers; quality control, quality assurance, and regulatory compliance personnel; and upper-level undergraduate and graduate students in these disciplines.

  • Reviews

    "

    the real picture of how biopharmaceuticals develop for market readiness

    …distinguishes itself….

    …compact, pithy….[The author] put his own unique stamp on this volume to complete the real picture of how biopharmaceuticals develop for market readiness."-Applied Genetics News, 1997

    Table of Contents

    Introduction to the Development of Biopharmaceutical Parenteral Dosage Forms, John A. Bontempo

    Fermentation Process Events Affecting Biopharmaceutical Quality, Anthony S. Lubiniecki

    Development of Recovery Processes for Recombinant Proteins and Peptides, Paula J. Shadle

    Preformulations Development of Parenteral Biopharmaceuticals, John A. Bontempo

    Formulations Development, John A. Bontempo

    The Analytical Techniques, Basant G. Sharma

    Membrane Filtration Technology, Forrest Badmington

    Considerations for Elastomeric Closures for Parenteral Biopharmaceutical Drugs, John A. Bontempo

    About the Series

    Drugs and the Pharmaceutical Sciences

    Learn more…

    Subject Categories

    BISAC Subject Codes/Headings:
    MED071000
    MEDICAL / Pharmacology