Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers e
PRINCIPLES AND MECHANISMS. Principles of Developmental Toxicology. Mechanisms of Developmental Toxicology. Pathogenesis of Abnormal Development. Maternally-Mediated Effects on Development. Paternally-Mediated Effects on Development. Comparative Embryology. HAZARD ASSESSMENT. Developmental Toxicity Testing - Single and Multiple Generation Test Methodology. Nonclinical Juvenile Toxicity Testing -- Methodology and Data Evaluation. Testing for Reproductive Toxicity in the Male and Female and Evaluation of the Data. Endocrine Disruption - Testing and Data Evaluation. Role of Xenobiotic Metabolism in Developmental Toxicity. Toxicokinetics. Cellular, Biochemical, and Molecular Techniques. Genomics and Proteomics. In Vitro Mechanistic Studies. Statistical Analysis. Quality Control - GLP for Toxicologists. Regulatory Test Guidelines. Epidemiologic Techniques in Development and Reproductive Toxicology. Risk Assessment - EPA Approach. Risk Assessment - FDA Approach. Appendices.