This problem-based guide illustrates key reasoning processes that physicians use to resolve individual clinical problems through the use of electron microscopy. Its format will facilitate learning the case approach for diagnostic ultrastructural pathology using clinical-ultrastructural-pathogenic correlation.
A total of 51 cases and a procedural guide for the ultrastructural pathology laboratory are included. The cases were selected according to one of the following four principles: 1) classic cases that were diagnosed readily by light microscopy to facilitate the electron microscopic diagnosis of less "classic" cases; 2) diagnostic cases, those cases for which ultrastructural analysis was essential for the diagnosis; 3) supportive cases, which are those cases where either the light or the electron microscopic diagnosis is supportive and confirmatory to the other; and 4) new facts cases, which are those that establish new knowledge regarding the pathogenesis of disease using electron microscopy as the investigative modality. The 51 cases are grouped anatomically in eight major categories. Separate indices for presenting symptoms, differential diagnostic groups, ultrastructural pathology criteria, and final diagnostic categories are provided, as well.
This guide will be useful to physicians and students of medicine, structure, and disease. It also makes an ideal operational guide and text for support staff training.
Cardiovascular System: Amyloidosis of the Heart. Gastrointestinal System: Granular Cell Tumor of the Stomach. Mucous Adenocarcinoma of the Stomach. Gastrinoma of the Jejunum (Zollinger-Ellison Syndrome). Whipple's Disease of the Small Intestine. Adenocarcinoma of Gut Absorptive Epithelial Cell Origin. Rectal Carcinoid Tumor. Midgut Carcinoid Tumor. Pouchitis of Continent Ileal Pelvic Pouch (Familial Multiple Polyposis). Crohn's Disease of the Ileum. Gastrointestinal Autonomic Nerve (GAN) Tumor of the Ileum. Nervous and Endocrine Systems: Neuroblastoma of the Small Intestine. Ganglioneuroma of the Posterior Mediastinum. Carotid Body Tumor, Paraganglioma. Hürthle Cell Carcinoma of the Thyroid. Growth Hormone Eosinophil Adenoma of the Pituitary (Acromegaly). Chromophobe Adenoma of the Pituitary. Prolactinoma of the Pituitary. Meningioma. Intracranial Dysgerminoma. Respiratory System and Anterior Mediastinum: Bronchiolo-Alveolar Carcinoma of the Lung (Scleroderma). Alveolar Carcinoma of the Lung Metastatic to Brain. Mucous Adenocarcinoma of the Lung Metastatic to Brain. Pulmonary Alveolar Proteinosis. Bronchial Carcinoid Tumor. Peripheral Pulmonary Carcinoid Tumor. Atypical Carcinoid Tumor of the Lung. Small Cell Carcinoma of the Lung. Thymoma. Malignant Thymoma. Primary Mediastinal Seminoma. Reticuloendothelial System: Primary Lymphoma of the Cerebellum. Primary Lymphoma of the Stomach. Primary Lymphoma of the Ileum. Primary B Cell Lymphoma of the Colon. Primary T Cell Lymphoma of the Skin (Mycosis Fungoides, Sezary Syndrome). Multiple Myeloma. Plasmacytoma. Skin: Merkel Cell Carcinoma. Melanoma Metastatic to Lung. Amelanotic Melanoma Metastatic to Breast. Amelanotic Melanoma Metastatic to Lung. Primary Amelanotic Melanoma of the Foot. Soft Tissues: Fibrosarcoma. Urogenital System: Adenoma and Adenocarcinoma of the Kidney. Renal Cell Carcinoma Metastatic to Lung. Leiomyosarcoma of the Uterus Metastatic to Lung. Procedural Guide to Specimen Handling for the Ultrastructural Pathology Service Laboratory.