Cholera and Diarrhoeal diseases continue to be a scourge of mankind, especially in the developing countries. One of the successful approaches to the control of diarrhoeal diseases is the use of mass vaccinations, but there are uncertainties about the effectiveness of old vaccines. Unfortunately, these vaccines have limited applications as the organism changes its character occasionally, rendering the vaccine ineffective. Although better sanitation and improved standards of living are still the best solutions to combat the endemic form of this disease, these are still far away goals in many countries.
Diarrhoeal Diseases: Research Perspectives highlights the new and emerging approaches to tackle these ancient diseases. Contributing authors discuss progress made in mapping of the genome Vibrio cholerae and the prospects of developing effective and specific vaccines. These articles indicate the direction of advanced research and will be valuable source material for all those interested in the management of these dreaded diseases.
Efforts towards the Development of Oral Cholera Vaccines in India against the Backdrop of Global Endeavours, Amit Ghosh, M. Thungapathra, C. Sharma, N. Gupta, R.K. Ghosh, A. Mukhopadhyay, H. Kole, and G.B. Nair
New Perspectives in the Epidemiology of Cholera, S.K. Bhattacharya
Spectrum of Gut Immunologic Reactions to New Vibrio cholerae and Its Toxin, K. Walia, H. Vohra, and N.K. Ganguly
Role of Microbial Agents and Micronutrient Deficiency in Aetiopathogenesis of Persistent Diarrhea in Young Children, M.K. Bhan, Nita Bhandari, and Shinjini Bhatnagar
Evolution of Rotaviruses in India: Natural Reassortant Asymptomatic Neonatal Rotaviruses as Potential Live Vaccine Candidates in Humans, C. Durga Rao
Molecular Mechanisms of Stable Toxin Mediated Diarrhoeas, Manjiri M. Bakre and Sandhya S. Visweswariah
Macro- and Micro-Diversity in the Genome of Vibrio cholerae, Jyotirmoy Das and Rupak K. Bhadra