Dictyostelium discoideum is a model eukaryotic organism for basic biomedical research in cell and developmental biology and for the functional analysis of sequenced genes. The organism has unique advantages for studying fundamental cellular processes such as cytokinesis, motility, phagocytosis, chemotaxis, signal transduction, cell sorting, pattern formation, and cell-type determination.
This book, written to coincide with the publication of the genome sequence of Dictyostelium, introduces the post-genomic era and focuses on the important aspects of Dictyostelium genomics. Leading experts in the field have contributed chapters on genomic mapping and sequencing, databases, multigene families, regulation of gene expression, signal transduction, the microfilament system, the GTPase superfamily, the kinome, glycosyltransferase genomics, and whole-genome functional analysis.
Table of Contents
1. Mapping and Sequencing the Dictyostelium Genome. 2. dictyBase: Using the Genome to Organize Dictyostelium Biology. 3. Metabolic Pathways. 4. Multigene Families of Dictyostelium. 5. Components of the Dictyostelium Gene Expression Regulatory Machinery. 6. Signal Transduction via G-Protein-Coupled Receptors, Trimeric G Proteins, and RGS Proteins. 7. The Microfilament System of Dictyostelium discoideum. 8. The Small GTPase Superfamily. 9. The Dictyostelium Kinome and Protein Kinase Pathways that Regulate Growth and Development. 10. Glycosyltransferase Genomics in Dictyostelium discoideum. 11. How Many Protein Encoding Genes Does Dictyostelium discoideum Have? 12. Whole-Genome Functional Analyses in Dictyostelium.
This is a gold mine of information for those interested in genomics research. A major strength of this book is that it provides up-to-date information, based on solid interpretation of the genome sequence... The book is clearly written, carefully edited, and east to read - B. A. Fenderson, Thomas Jefferson University, USA, Doody'e Book Review Service