1st Edition

Dietary Polyphenols in Human Diseases Advances and Challenges in Drug Discovery

Edited By Mithun Rudrapal Copyright 2023
    300 Pages 17 Color & 24 B/W Illustrations
    by CRC Press

    300 Pages 17 Color & 24 B/W Illustrations
    by CRC Press

    Diets rich in plant polyphenols or dietary polyphenols are the subject of increasing scientific interest because of their diverse range of health benefits and medicinal uses. This book, Dietary Polyphenols in Human Diseases: Advances and Challenges in Drug Discovery, fills the gap that exists in the current knowledge by presenting the latest information in the area of polyphenol-based drug discovery research. The book focuses on the current understanding of the beneficial effects on human health of diets rich in polyphenols and/or polyphenolic compounds derived from dietary sources (plant-based foods) and their possible preventive role in the management of chronic human diseases. In addition, biochemical mechanisms involved in the antioxidative effect of dietary polyphenols along with their bioavailability, pharmacokinetic, and toxicological considerations are also discussed herein.

    Key Features

    • Presents health benefits and medicinal importance of dietary polyphenols having antioxidative effects and their possible preventive role against oxidative stress (OS)-induced chronic human diseases.
    • Summarizes the latest understanding of the biochemical mechanism(s) involved in the antioxidative action of dietary polyphenols along with their bioavailability, pharmacokinetic, and toxicological considerations.
    • Highlights novel approaches of drug discovery from dietary polyphenols through computational screening of bioactive phytochemical components.

    With contributions by a global team of experts (academics, scientists, and researchers), this book is intended to be a useful resource for a wider audience, particularly those working in the area of drug discovery and development research, such as discovery scientists, pharmaceutical scientists (R&D), formulation scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, clinicians, researchers, students, teachers, and many others.

    Chapter 1: Dietary Polyphenols, Antioxidant Effects, and Human Diseases

    Himadri Kalita, Prashanta Kumar Deb, Rajdeep Saha, Amrita Chatterjee, Suparna Roy Sarkar, Satish Kumar, and Biswatrish Sarkar

    Chapter 2: Biochemical, Molecular, Pharmacokinetic, and Toxicological Aspects of Dietary Polyphenols

    Yousef Rasmi, Aline Priscilla Gomes da Silva, Sahar Rezaei, Safa Rafique, and Muhammad Zeeshan Ahmed

    Chapter 3: Dietary Polyphenols in Aging, Neurological, and Cognitive Disorders

    Lalit Mohan Nainwal and Poonam Arora

    Chapter 4: Dietary Polyphenols in Cancer

    Ashish Shah, Vaishali Patel, and Ghanshyam Parmar

    Chapter 5: Dietary Polyphenols in Cardiovascular Diseases (CVDs)

    Johra Khan and Mithun Rudrapal

    Chapter 6: Dietary Polyphenols in Arthritis and Inflammatory Disorders

    Lalit Mohan Nainwal and Poonam Arora

    Chapter 7: Dietary Polyphenols in Diabetes

    Yousef Rasmi, Safa Rafique, Quratulain Babar, Behrokh Daei-Hasani, and Yeganeh Farnamian

    Chapter 8: Dietary Polyphenols in Bacterial and Fungal Infections

    Veda Joshi, Swarangi Tambat, Mustansir Bhori, Jyotirmoi Aich, and Kanchanlata Tungare

    Chapter 9: Dietary Polyphenols in Viral Infections

    Vishal K. Singh, Jayati Dwivedi, Aditya K. Yadav, and Ramendra K. Singh

    Chapter 10: Dietary Polyphenols in Parasitic Diseases and Neglected Tropical Diseases (NTDs)

    James H. Zothantluanga, Arpita Paul, Ngurzampuii Sailo, Zonunmawii, H. Lalthanzara, and Dipak Chetia

    Chapter 11: Dietary Polyphenols for the Management of Skin Diseases and Wound Healing

    Shiv Kumar Prajapati, Dolly Jain, Sapna Joshi, Payal Kesharwani, and Siddhartha Maji

    Chapter 12: Dietary Polyphenols from Spice and Their Impact on Human Health

    Neelesh Kumar Nema, Nayana Rajan, Merin Babu, Sachithra Sabu, Swapnil Devidas Khamborkar, Smitha Sarojam, Linson Cheruveettil Sajan, Aneena Peter, Baby Kumaranthara Chacko, and Viju Jacob

    Chapter 13: Dietary Polyphenols in Drug Discovery by Drug Repurposing and Computational Screening

    Ipsa Padhy, Aastha Mahapatra, Fahima Dilnawaz, and Tripti Sharma


    Mithun Rudrapal, PhD, FIC, is Associate Professor and Head at the Department of Pharmaceutical Chemistry, Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research (affiliated with Savitribai Phule Pune University), Pune, Maharashtra, India. Dr. Rudrapal works in Medicinal Chemistry, CADD, Drug Repurposing, Phytochemistry, Herbal Drugs, and Nanophytotherapeutics.