Digital Microfluidic Biochips: Synthesis, Testing, and Reconfiguration Techniques, 1st Edition (Hardback) book cover

Digital Microfluidic Biochips

Synthesis, Testing, and Reconfiguration Techniques, 1st Edition

By Krishnendu Chakrabarty, Fei Su

CRC Press

228 pages | 162 B/W Illus.

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Hardback: 9780849390098
pub: 2006-10-10
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Description

Digital Microfluidic Biochips focuses on the automated design and production of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Bridging areas of electronic design automation with microfluidic biochip research, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips.

The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constraints. Part II investigates cost-effective testing techniques for digital microfluidic biochips that include test resource optimization and fault detection while running normal bioassays. Part III focuses on different reconfiguration-based defect tolerance techniques designed to increase the yield and dependability of digital microfluidic biochips.

Expanding upon results from ongoing research on CAD for biochips at Duke University, this book presents new design methodologies that address some of the limitations in current full-custom design techniques. Digital Microfluidic Biochips is an essential resource for achieving the integration of microfluidic components in the next generation of system-on-chip and system-in-package designs.

Table of Contents

PART I

SYNTHESIS TECHNIQUES

Introduction

Technology Issues

Digital Microfluidic Biochips

Microfluidic Biochip Design Challenges

Book Outline

Architectural-Level Synthesis

Background

High-Level Synthesis Methodology

Simulation Experiments

Module Placement

Background

Module Placement Problem

Fault Tolerance for Digital Microfluidic Biochips

Experimental Evaluation

Unified Synthesis Methodology

Problem Formulation

PRSA-Based Algorithm

Enhancement for Defect Tolerance

Experimental Evaluation

Droplet Routing

Background

Problem Formulation

Routing Method

Experimental Evaluation

PART II

TESTING TECHNIQUES

Test Methodology

Background

Classification of Faults

Unified Detection Mechanism

Parametric Fault Testing

Simulation Experimental Setup

Test Planning

Problem Definition

Analysis of Computational Complexity

Integer Linear Programming Model for OPP

Heuristic Algorithms

Simulation Results

Concurrent Testing

Concurrent Testing Methodology

Optimal Scheduling for Concurrent Testing

Concurrent Testing Example

Defect-Oriented Testing and Diagnosis

Fault Modeling

Defect-Oriented Experiment

Testing and Diagnosis

Real-Life Application

PART III

RECONFIGURATION TECHNIQUES

Reconfiguration Schemes

Proposed Reconfiguration Schemes

Example Evaluation

Defect Tolerance Based on Space Redundancy

Background

Microfluidic Array with Hexagonal Electrodes

Defect-Tolerant Designs

Estimation of Yield Enhancement

Evaluation Example

Defect Tolerance Based on Graceful Degradation

Tile-Based Architecture

Clustered Defect Model

Graceful Degradation with Reconfiguration

Simulation Results

Conclusions and Future Work

Contributions of the Book

Future Work

Bibliography

Index

Subject Categories

BISAC Subject Codes/Headings:
MED009000
MEDICAL / Biotechnology
TEC008070
TECHNOLOGY & ENGINEERING / Electronics / Microelectronics
TEC027000
TECHNOLOGY & ENGINEERING / Nanotechnology & MEMS