Dopamine – Glutamate Interactions in the Basal Ganglia (Hardback) book cover

Dopamine – Glutamate Interactions in the Basal Ganglia

Edited by Susan Jones

© 2011 – CRC Press

284 pages | 3 Color Illus. | 20 B/W Illus.

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Hardback: 9781420088793
pub: 2011-12-14
eBook (VitalSource) : 9781420088809
pub: 2016-04-19
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The basal ganglia are involved in complex brain functions, from voluntary movement control to learning and reward processing, and they are implicated in numerous neurological and psychiatric disorders. Information from the cerebral cortex and thalamus is conveyed to basal ganglia nuclei via glutamate release, while dopamine from the midbrain is released in close proximity to glutamate. At the heart of both function and dysfunction of basal ganglia circuits is the interaction of these two neurotransmitters, dopamine and glutamate.

Elucidating the relationship between their molecular and cellular effects and behavioural significance has been challenging, but in the past 5–10 years, improved labeling, imaging, recording, and genetic manipulation approaches have yielded new information on how dopamine and glutamate interact to generate the circuit activity underpinning basal ganglia function. Dopamine–Glutamate Interactions in the Basal Ganglia synthesizes this recent researchfrom the level of receptor molecules all the way to complex behaviours and disease.

Current insights from research on individual neurons and synapses, detailed circuit analysis, and learning and action functions of the basal ganglia are presented against a historical perspective. The book also discusses compromised dopamine–glutamate interaction in disorders of basal ganglia function, including Parkinson’s disease, Huntington’s disease, and drug addiction.

Table of Contents

Metabotropic Glutamate Receptor–Dopamine Interactions in the Basal Ganglia Motor Circuit, Kari A. Johnson and P. Jeffrey Conn

Ionotropic Glutamate Receptors in the Basal Ganglia, Susan Jones, Shona L.C. Brothwell, Isabel Huang-Doran, and James Hallett

Dopamine Receptors and their Interactions with NMDA Receptors, Alasdair J. Gibb and Huaxia Tong

Synaptic Triad in the Neostriatum: Dopamine, Glutamate, and the MSN, Jason R. Klug, Ariel Y. Deutch, Roger J. Colbran, and Danny G. Winder

Dopaminergic Modulation of Glutamatergic Synaptic Plasticity in Striatal Circuits: New Insights from BAC-Transgenic Mice, D. James Surmeier, Weixing Shen, Tracy S. Gertler, and C. Savio Chan

Striatal Acetylcholine–Dopamine Crosstalk and the Dorsal–Ventral Divide, Sarah Threlfell and Stephanie J. Cragg

Electrophysiology of the Corticostriatal Network In Vivo, Morgane Pidoux, Séverine Mahon, and Stéphane Charpier

Functional Organization of the Midbrain Substantia Nigra, Jennifer Brown

Striatal Dopamine and Glutamate in Action: The Generation and Modification of Adaptive Behavior, Henry H. Yin and Rui M. Costa

Impaired Dopamine–Glutamate Receptor Interactions in Some Neurological Disorders, Miriam A. Hickey and Carlos Cepeda


About the Series

Frontiers in Neuroscience

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Anatomy
SCIENCE / Life Sciences / Cytology
SCIENCE / Life Sciences / Neuroscience