Drug Abuse Handbook: 2nd Edition (Hardback) book cover

Drug Abuse Handbook

2nd Edition

Edited by Steven B. Karch, MD, FFFLM

CRC Press

1,285 pages | 169 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9780849316906
pub: 2006-12-21
eBook (VitalSource) : 9780429245114
pub: 2006-12-21
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Following the well-received first edition, the Drug Abuse Handbook, Second Edition is a thorough compendium of the knowledge of the pharmacological, medical, and legal aspects of drugs. The book examines criminalistics, pathology, pharmacokinetics, neurochemistry, treatment, as well as drugs and drug testing in the workplace and in sports, and the ethical, legal, and practical issues involved.

Dr. Karch gathers contributions from 80 leading experts in their respective fields to update and revise this second edition with more than 40 percent new material. New topics include genetic testing in drug death investigation, the neurochemistry of nicotine and designer amphetamines, genetic doping in sports, and the implications of the Daubert ruling on the admissibility of scientific evidence in federal court.

Packed with the latest information in an easily accessible format, the book includes tables of all Scheduled Drugs, methods of Drug Quantitative Analysis, and a glossary of forensic toxicology terms. Vivid pictures and diagrams illustrate the pathological effects of drugs and the chemical make-up and breakdown of abused drugs. It includes more than 6000 references to the best sources in medicine, pharmacology, and the law.

This book addresses specific problems in drug testing, drug-related medical emergencies, and the physical, neurochemical, and sociological phenomenon of addiction. With unparalleled detail and the highest level of authoritative information, The Drug Abuse Handbook, Second Edition is the definitive resource for drug related issues.


"…Virtually no stone is left unturned. This is the most comprehensive volume I have ever had the pleasure of reading."

- Joseph Horvat, Weber State University, Ogden, Utah, in Science Books and Films

". . . extensive and comprehensive text . . . This is a reference work but also a very useful volume for academics, scientists, lawyers and medical practitioners who wish a very good starting point for a wide range of issues and topics relevant to drug abuse."

– James Robertson, National Manager, Forensic and Technical Australian Federal Police, September 2008

Table of Contents

Criminalistics: Introduction to Controlled Substances, J. P. Bono

Definition and Scheduling of Controlled Substances

Scheduling of Controlled Substances

Controlled Substance Analogue Enforcement Act of 1986

Controlled Substances

Legitimate Pharmaceutical Preparations

Unique Identify Factors

Analyzing Drugs in the Forensic Science Laboratory

Comparative Analysis

Clandestine Laboratories

Pathology of Drug Abuse, Edited by C. V. Wetli

The Scene of Death and the Autopsy

Heart Disease

Myocardial Alterations in Drug Abusers, S. B. Karch

Valvular Heart Disease, M. D. Bell

Lung Disease, M. D. Bell

Disorders of the Central Nervous System, M. Bell

Pharmacokinetics: Drug Absorption, Distribution, and Elimination, A. J. Jenkins

Basic Concepts and Models

Pharmacokinetic Modeling

Pharmacokinetic-Pharmacodynamic Correlations


Factors Affecting Pharmacokinetic Parameters

Pharmacokinetics of Specific Drugs

Pharmacodynamics, Edited by S. J. Heishman

Effects of Abused Drugs on Human Performance: Laboratory Assessment, S. J. Heishman and C. S. Myers

Performance-Based Assessment of Behavioral Impairment in Occupational Settings, T. H. Kelly, R. C. Taylor, S. J. Heishman, and J. Howland

Effects of Pupillometry and Eye Tracking as Predictive Measures of Drug Abuse, W.B. Pickworth and Rudy Murillo

Abuse of Marketed Medications, K. L. Preston, D. H. Epstein, J. P. Schmittner, and S. L. Walsh


Measuring Acute Alcohol Impairment

Update on Clinical and Forensic Aspects of Alcohol, A. W. Jones and D. J. Pounder

Post-Mortem Alcohol - Aspects on Interpretation, D. J. Pounder and A. W. Jones

Recent Advances in Biochemical Tests for Acute and Chronic Alcohol Consumption, A. Helander and A. W. Jones

Neurochemistry of Drug Abuse, Edited by J. K. Staley and K. P. Cosgrove

The Dopamine Transporter and Addiction, W. M. Meil1 and J. W. Boja

Neurochemistry of Nicotine Dependence, D. H. Brunzell

Neurochemical Substrates of Habitual Tobacco Smoking, I. Esterilis, S. Krishnan-Sarin, and J. K Staley

Neurochemical and Neurobehavioral Consequences of Methamphetamine Abuse, C. N. Haile.

Neurochemical Adaptations and Cocaine Dependence, K. P. Cosgrove and J. K. Staley

Neuropsychiatric Consequences of Chronic Cocaine Abuse, D. C. Mash

Neurobiology of 3,4-Methylenedioxymethamphetamine (MDMA, or "Ecstasy"), M. H. Baumann and R. B. Rothman

Addiction Medicine, Edited by K. Wolff

The Principles of Addiction Medicine, D. Raistrick

Substitute Prescribing, K. Wolff

Treatment of Withdrawal Syndromes, J. Banbery

Replacement Prescribing, K. Wolff

Management of Comorbidity

Toxicologic Issues

Medical Complications of Drug Abuse, N. L. Benowitz

Medical Aspects of Drug Abuse, S. Zevin and N. L. Benowitz

Emergency Management of Drug Abuse, B. A. Roth, N. L. Benowitz, and K. R. Olson

Sports, Edited by M. D. Bollmann and M. Saugy

Testosterone and Synthetic Anabolic Steroids, C. Saudan and N. Baume

Stimulants, L. Avois-Mateus

Erythropoietin - Blood Doping, N. Robinson

Human Growth Hormone, M. Saugy

Cannabinoids, C. Giroud

Ethanol Use in Sport and Interaction with Other Doping Agents

Morbidity of Doping, M. D. Bollmann and P. Mangin

Mortality of Doping - Sudden Death in Athletes, M. D. Bollmann

The Future of Doping: New Drugs and Genetic Doping, C. Giroud and M. D. Bollmann

Workplace Testing, Edited by Y. H. Caplan and M. A. Huestis

Drugs in the Workplace, Y. H. Caplan and M. A. Huestis

Federal Regulation of Workplace Drug and Alcohol Testing

Workplace Drug Testing outside the U.S., A. Pierce

Analytical Considerations and Approaches for Drugs, D. Isenschmid and B. A. Goldberger

Analytical Approaches for Drugs in Biological Matrices Other Than Urine, P. Kintz, M. Villain, and V. Cirimele

Interpreting Alternative Matrix Test Results, E. J. Cone, A. Sampson-Cone, and M. A. Huestis

Specimen Validity Testing, Y. H. Caplan

The Role of the Medical Review Officer in Workplace Drug Testing, J. A. Thomasino

Quality Practices in Workplace Testing, J. M. Mitchell and F. M. Esposito

Current Legal Issues of Workplace Drug Testing, T. F. Shults

Point of Collection Drug Testing

Point of Collection Testing of Alternative Specimens (Other Than Urine), A. Verstraete and J. M. Walsh

Point of Collection Testing in Criminal Justice, L. Kadehjian

Regulatory Concerns for Point of Collection Testing in the Workplace, M. R. Baylor, C. A. Sutheimer, and S. D. Crumpton

Determination of Alcohol in Point of Collection Testing, J. R. Zettl

On-Site Point-of-Collection Drug Testing: History, Development, and Applications, J. Tsai

Post-Mortem Toxicology, Edited by H. Druid

Introduction to Postmortem Toxicology, W. L. Hearn and H. C. Walls

Specimen Selection, Collection, Preservation, and Security, B. R. Hepler and D. S. Isenschmid

Common Methods in Post-Mortem Toxicology, W. L. Hearn and H. C. Walls

Strategies for Post-Mortem Toxicology Investigation, Edited and Revised by H. Druid, from the original by W. L. Hearn

Quality Assurance in Post-Mortem Toxicology, W. Andollo

Interpretation of Post-Mortem Drug Levels, G. R. Jones


Pharmacogenomics for Toxicology, R. M. White, Sr. and S. H. Y. Wong

Heritable Channelopathies and Myopathies, K. A. Glatter, J. Calkins, and S. J. Ayirookuzhi

Drug Law

DUI Defenses, A. W. Jones and B. K. Logan

Testing Claims of Adverse Drug Effects in the Courtroom, J. G. Hollingsworth and E.G. Lasker


Appendix Ia: Glossary of Terms in Forensic Toxicology, Compiled by C. Walls

Appendix Ib: Common Abbreviations, Compiled by C. Walls

Appendix Ic: References for Methods of Drug Quantitative Analysis

Appendix II: Sample Calculations, B. K. Logan and A. W. Jones

Appendix III: Predicted Normal Heart Weight (g) as a Function of Body Height in 392 Women and 373 Men


Subject Categories

BISAC Subject Codes/Headings:
LAW / Forensic Science
MEDICAL / Psychiatry / General
SOCIAL SCIENCE / Criminology