The worldwide impact of HIV/AIDS is well recognized. This book provides for the first time a thorough and critical overview of current aspects, recent developments, and trends in the formulation and drug delivery concerning anti-HIV microbicides by leading scientists in the field. Additionally, pertinent regulatory aspects and socioeconomical issue
Preface. Microbicides and the HIV Pandemic. HIV Transmission Models: Lessons Learned for Microbicide Formulation Design. Challenges in Microbicide Drug Delivery: Identifying Targets and Evolving Strategies. Safety Issues Related with Microbicide Formulations. Biophysics, Drug Transport Modeling and Performance of Microbicide Formulations. Dosage Forms for Microbicides Formulation: Advantages and Pitfalls. Microbicide Vaginal Rings. Vaginal Microbicide Films. Rectal Microbicide Development, Formulation and Delivery. Design of Stimuli-Sensitive Microbicide Formulations. Nanotechnology-Based Systems for Microbicide Development; Nanofibers for Microbicide Drug Delivery. Modified Microflora for Microbicide Drug Delivery. Scale-up, Affordability and Intellectual Property Issues Related with Microbicide Formulation Development. Regulatory Issues Pertaining Microbicide Products.Socioeconomic and Behavioral Factors Influencing Choice, Adherence and Success of Microbicide Formulations.