Drug Development for Cancer and Diabetes: A Path to 2025, 1st Edition (Hardback) book cover

Drug Development for Cancer and Diabetes

A Path to 2025, 1st Edition

Edited by K. Saravanan, Chukwuebuka Egbuna, Horne Iona Averal, S. Kannan, S. Elavarasi, Bir Bahadur

Apple Academic Press

355 pages | 13 Color Illus. | 31 B/W Illus.

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Hardback: 9781771888608
pub: 2020-03-15
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Drug Development for Cancer and Diabetes: A Path to 2030 focuses on new developments in the discovery of drugs for the treatment of cancer and diabetes. This new book presents important recent advances, emerging trends, and novel innovations for these two world-leading diseases. It is structured in two parts. Part I consists of chapters that explores cancer cell cycle checkpoints, cancer biomarkers, essential drug properties, stages in anti-cancer drug development, and various bioactives that are effective against cancer. Part II presents a complete coverage of important advances and research discoveries in antidiabetic drugs. It details the potentials of medicinal plants and phytocompounds as sources for antidiabetic drugs and highlights the ethnobotanical basis of the compounds.

With chapters written by professionals in the field of phytochemistry and pharmacology from key institutions around the world, this volume provides a wide coverage and will be useful especially for scientists in pharmaceutical field.

Table of Contents

Part 1: Cancer And Leads For Cancer Treatment

1. Biomarkers for Screening of Premalignant Lesions and Therapeutic Surveillance

Chukwuebuka Egbuna

2. Kinase Targets in Cancer Drug Discovery

S. Usha

3. Essential Drug Properties and Stages in Anti-Cancer Drug Development

Andrew G. Mtewa, Duncan Sesaazi, Annu Amanjot and Serawit Deyno

4. Plant Constituents as Anti-Cancer Drugs

T. Veni, T. Pushpanathan, and G. Vimala

5. Anticancer Properties of Some Effective Phytochemicals

Murat Alan and Behnaz Aslanipour

6. Therapeutic Aspects of Some Extracts and Purified Cardiac Glycosides Obtained from Nerium oleander L.

Behnaz Aslanipour and Murat Alan

7. Challenging Compounds of Some Medicinal Plants against Cancer

N. Shaista Jabeen et al.

8. Medicinal Plants as Therapeutic Agents in the Treatment of Cancer

Jaya Vikaskurhekar

9. Cytotoxic and Apoptosis-Inducing Effects and Anti-Cancerous Drug Candidature of Jasmonates

T. Parth et al.

10. Apoptosis Activity of 1, 2, Benzne Dicarboxylic Acid Isolated from Andrographis paniculata on KB, SiHa and IMR Cancer Cell Lines

P. Krishnamoorthy and D. Kalaiselvan

11. Anticancer Drug Discovery from the Indian Spice Box

M. V. N. L. Chaitanya et al.Reddy

12. Phytochemical Investigation and Evaluation of Antibreast Cancer Activity of Chloroform Extract of Tagetes erecta

R. Arul Priya, K. Saravanan, and Chukwaebuka Egbuna

13. Isolation, Identification, and in Silico Evaluation of Anticancer Activity of Flavone from Pisum sativum

R. Arul Priya, K. Saravanan, and P. Karuppannan

14. Functional Lead Phytocheicals from the Rutaceae and Zingiferaceae Plants for Development of Anticancer Drugs

K. Saravanan et al.

15. In Vitro Anticancer Activity of Biophytum sensitivum on Liver Cancer Lines (HepG2)

M. P. Santhi, K. Saravanan, and P. Karuppannan

16. Saffron and Its Active Ingredients: A Natural Product with a Potent Anticancer Property

Ashutosh Gupta and Abhay K. Pandey

Part 2: Antidiabetic Drug Discovery

17. Effects of Pterocarpus marsupium in the Management of Type 2 Diabetes Mellitus

Priscilla Suresh

18. Antidiabetic and Antihyperlipedemic Activities of Cyathea nilgiriensis (Holttum) on STZ-Induced Diabetic Rats

S. Elavarasi et al.

19. Antidiabetic Activity of Drug-Loaded Chitosan Nanoparticles

G. Revathi, S. Elavarasi, and K. Saravanan

20. Antidiabetic Activity of Silver Nanoparticles Biosynthesized Using Ventilago maderaspatana Leaf Extract

P. Karuppannan, K. Saravanan, and Horne Iona Averal

21. Hypoglycemic Activity of Biophytum sensitivum Whole Plant Extracts on Alloxan-Induced Diabetic Rats

C. Renuka, K. Saravanan, and P. Karuppannan

22. Antidiabetic Activity of Ventilago maderaspatana Leaf Extracts on STZ-Induced Diabetic Rats

P. Karuppannan, K. Saravanan, and P. Premalatha

23. Isolation, Identification, and Molecular Docking of Antidiabetic Compounds of Cytheia nilgiriensis (Holttum)

S. Elavarasi, G. Revathi, and K. Saravanan

24. Antidiabetic Potentials of Major Indian Spices: A Review

Pratibha et al.

25. Aloe Species: Chemical Composition and Therapeutic Uses in Diabetic Treatment

Amit Kumar Singh et al.


About the Editors

K. Saravanan, PhD, is Associate Dean of Academic Affairs and Assistant Professor of Zoology, Nehru Memorial College (Autonomous), an affiliated institution of Bharathidasan University, Tiruchirappalli, Tamilnadu, India.

Chukwuebuka Egbuna is a chartered chemist, a chemical analyst, and an academic researcher. He is a member of the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), the Society of Quality Assurance (SQA) (USA), and the Royal Society of Chemistry (RSC) (United Kingdom).

Horne Iona Averal, PhD, is an Associate Professor at Holy Cross College, Trichy, India.

Soundarapandian Kannan, PhD, is a specialist in cancer biology and nanomedicine. He has been engaged in a number of roles at national and international academic and scientific bodies. He has collaboratively worked and published a large number of research articles in the area of nanomedicines related to cancer.

S. Elavarasi, PhD, is an Assistant Professor at Holy Cross College, an affiliated institution of Bharathidasan University, Tiruchirappalli, Tamilnadu, India.

Bir Bahadur, PhD, was formerly Professor, Chairman, and Head of the Department, as well as Dean of the Faculty of Science at Kakatiya University in Warangal, India, and has also taught at Osmania University in Hyderabad, India.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
MEDICAL / Pharmacy
SCIENCE / General