Drug Metabolism: Chemical and Enzymatic Aspects, 1st Edition (Hardback) book cover

Drug Metabolism

Chemical and Enzymatic Aspects, 1st Edition

By Jack P. Uetrecht, William Trager

CRC Press

179 pages | 179 B/W Illus.

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Hardback: 9780849375958
pub: 2007-06-20
eBook (VitalSource) : 9780429131974
pub: 2007-06-20
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In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structure and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This title is a comprehensive guide for recognizing the chemical underpinnings of drug metabolism. While there are numerous resources available to medicinal chemists for understanding drug structure, and to pharmacologists for discerning drug metabolism from a biological standpoint, no resource currently exists that links the chemical and biological aspects in language accessible to both-making it challenging for both groups to fully comprehend how a drug is metabolized, as well as the potential effects of the metabolites. Drug Metabolism: Chemical and Enzymatic Aspects provides extensive material to help understand drug metabolism within a biological context, and for predicting and mitigating adverse drug reactions.

Table of Contents

Background for Non-Chemists. Background for Chemists. Oxidation Pathways and the Enzymes That Mediate Them. Reductive Pathways. Hydolytic Pathways. Conjugation Pathways. Reactive Metabolites

About the Authors

Uetrecht\, Jack P.; Trager\, William

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
MEDICAL / Pharmacy
SCIENCE / Chemistry / General