This book focuses on current research into both Ebola and Marburg viruses. Emphasis is placed on the genomics of the viruses, their molecular properties and their taxonomy. Further chapters consider how the viruses evolve and replicate and there are discussions on the spread of these viruses and their pathogenicity.
This book presents a comprehensive review of the current research on these highly virulent viruses. Topics covered include the genomics of the Filoviridae, molecular properties, taxonomy, replication, evolution, epidemiology, pathogenicity, virus-host interactions and the immune response.
Table of Contents
1. Transcription and Replication of Filoviruses. 2. Virus Maturation. 3. Iosynthesis and Function of Viral Proteins. 4. Biosynthesis and Function of Viral Proteins. 5. Structure of Viral Proteins. 6. Filovirus Receptors and Entry. 7. Filovirus Pathogenesis in Humans. 8. Filovirus Pathogenesis in Non-human Primates. 9. Ebola Virus Pathogenesis in a Guinea Pig Model. 10. Pathogenesis of Filovirus Infection in Mice. 11. Host Factors in Pathogenesis. 12. Modulation of Innate Immunity by Filoviruses. 13. Immune Response to Filovirus Infection. 14. Vaccination Against Filoviruses. 15. Filoviruses, Pathogenesis and Vaccines.
This is a fascinating update on the molecular biology, pathogenesis and immunology of viruses of the Filoviridae family. The Editors have done a marvellous job collating up-to-date reviews by leading research groups in the field. - Microbiology Today (May 2004)
This book presents a comprehensive review of curent research on Ebola and Marburg viruses...Researchers and students alike will find this book very useful.
- CAB Abstracts
Virologists will be most interested in this book, but it would also be useful to biologists and students interested in electron microscopy techniques and infectious diseases. Programs in infectious disease, international health and veterinary and zoonotic diseases will want to have this book in their collections. It is recommended for all biology and biomedical science library collections. - E-Streams (Vol. 7, No. 8 - August 2004)
This is an excellent reference for anyone doing research with these viruses as well as for educators in virology. - Doody's Book Review
It is highly recommended to medical staff such as virologists and infectious disease physicians as well as to scientific staff interested in molecular biology and immunology of these interesting and significant viral pathogens. - American Journal of Medical Science, August 2005, Vol 27, No. 3