There is great concern regarding the reproductive and health hazards of endocrine disruptors. Research indicates that men are experiencing declining fertility and an increased incidence of prostate cancer, while women are dealing with increased infertility, early menopause, and breast cancer. As new research reveals the previously unknown risks of these endocrine disruptors, it is imperative to update our knowledge of these controversial chemicals.
Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition examines the reproductive and health hazards of endocrine-disrupting environmental chemicals from epidemiology to etiology, concluding with future directions. Divided into two sections, the first part of the book describes the effects of environmental toxicants on the female reproductive system, with an emphasis on the effects and mechanisms of their action on sex differentiation during development, fertility, and breast cancer. The second part addresses the effects of endocrine disruption on the male reproductive system, focusing on male fertility and the development of benign prostate hyperplasia (BPH) and prostate cancer.
Leading authorities contribute expert analyses and up-to-date information on a topic that has become a major concern among the scientific community and the general public. This second edition supplies the most current, critical knowledge on the real risks that endocrine disruptors pose to the population.
Effect on the Female Reproductive System. Disruption of Nongenomic Steroid Actions on Gametes and Serotonergic Pathways Controlling Reproductive Neuroendocrine Function by Environmental Chemicals. Developmental and Reproductive Abnormalities Associated with Environmental Estrogens: Diethylstilbestrol (DES) as an Example. Ovotoxic Environmental Chemicals: Indirect Endocrine Disruptors. p,p'-DDE and HCB: Mechanisms of Toxicity to Fetal and Embryonic Mammalian Cells. Dietary Phytoestrogens. Estrogens, Xenoestrogens and the Development of Neoplasms. Molecular Mechanisms of Endocrine Disruption in Estrogen Dependent Processes. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Environmental Antiestrogens: Characterization and Mechanism of Action. Effect on the Male Reproductive System. Endocrine Disruptors and Male Infertility. Environmental Androgens and Antiandrogens: An Expanding Chemical Universe. Endocrine Disruptors and Male Sexual Dysfunction. Prostate Development: Mechanisms for Opposite Effects of Low and High Doses of Estrogenic Chemicals. Metal Ions as Endocrine Disruptors: Implications for Prostate Cancer.