Endothelins in Biology and Medicine: 1st Edition (Hardback) book cover

Endothelins in Biology and Medicine

1st Edition

By John P. Huggins, John T. Pelton

CRC Press

400 pages

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Hardback: 9780849369759
pub: 1996-12-23
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Endothelin-1 (ET-1), a peptide discovered in 1988, is one of the most potent contractors of vascular smooth muscle. Since their discovery, ETs have generated enormous interest in the scientific and pharmaceutical communities, prompting extensive research. This book addresses the latest findings regarding ETs-how they function, their effects, and characteristics. Divided into five sections, the book covers: endothelin receptors, endothelin synthesis and degradation, endothelin pathophysiology, ligand structure and activity relationships, and clinical studies. Pharmacologists, toxicologists, and pharmaceutical researchers will all benefit from this thorough review of current findings and future directions in ET research.

Table of Contents

Endothelin Receptors

Endothelin Receptors: Pharmacological Subtyping, Agonists and Antagonists, C.R. Hiley

Endothelin Receptor Molecular Biology, J.P. Huggins

Distribution of Endothelin Receptors, A.P. Davenport

Peptide Receptor Interactions, D. Guedin, C. Frelin, and P. Vigne

Endothelin-Induced Intracellular Signaling Pathways, H. Schramek and M.J. Dunn

Endothelin Synthesis and Degradation

Endothelin Converting Enzymes and Related Inhibitors, M. Biguad and H. D'Orchymont

Endothelin Metabolism, S. Kaw and M. Yanagisawa

Endothelin Pathophysiology

Cardiovascular Effects of Endothelin, B. Gumusel, Q. Hao, J.K. Chang, A. Hyman, and H. Lippton

Effects of Endothelin in the Kidney, P. Nambi and D.P. Brooks

Endothelin-Induced Responses in the Pulmonary System, B. Battistini and T.D. Warner

Effects of Endothelins on the Nervous System, M. van den Buuse

Urogenital Actions of Endothelins, K.S. Sang and J.P. Huggins

Endothelin in the Eye, N.N. Osborne

Ligand Structure and Activity Relationships

Conformational Studies of Endothelins and Analogs, J.T. Pelton

Endothelin Agonists, J.T. Pelton

Development of Endothelin Agonists, A.M. Doherty and W.C. Patt

Clinical Studies

Clinical Pharmacology and Pathophysiology of the Endothelins, W.G. Haynes and D.J. Webb

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
MEDICAL / Pharmacology