Endothelins in Biology and Medicine  book cover
1st Edition

Endothelins in Biology and Medicine

ISBN 9780849369759
Published December 23, 1996 by CRC Press
400 Pages

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Book Description

Endothelin-1 (ET-1), a peptide discovered in 1988, is one of the most potent contractors of vascular smooth muscle. Since their discovery, ETs have generated enormous interest in the scientific and pharmaceutical communities, prompting extensive research. This book addresses the latest findings regarding ETs-how they function, their effects, and characteristics. Divided into five sections, the book covers: endothelin receptors, endothelin synthesis and degradation, endothelin pathophysiology, ligand structure and activity relationships, and clinical studies. Pharmacologists, toxicologists, and pharmaceutical researchers will all benefit from this thorough review of current findings and future directions in ET research.

Table of Contents

Endothelin Receptors
Endothelin Receptors: Pharmacological Subtyping, Agonists and Antagonists, C.R. Hiley
Endothelin Receptor Molecular Biology, J.P. Huggins
Distribution of Endothelin Receptors, A.P. Davenport
Peptide Receptor Interactions, D. Guedin, C. Frelin, and P. Vigne
Endothelin-Induced Intracellular Signaling Pathways, H. Schramek and M.J. Dunn
Endothelin Synthesis and Degradation
Endothelin Converting Enzymes and Related Inhibitors, M. Biguad and H. D'Orchymont
Endothelin Metabolism, S. Kaw and M. Yanagisawa
Endothelin Pathophysiology
Cardiovascular Effects of Endothelin, B. Gumusel, Q. Hao, J.K. Chang, A. Hyman, and H. Lippton
Effects of Endothelin in the Kidney, P. Nambi and D.P. Brooks
Endothelin-Induced Responses in the Pulmonary System, B. Battistini and T.D. Warner
Effects of Endothelins on the Nervous System, M. van den Buuse
Urogenital Actions of Endothelins, K.S. Sang and J.P. Huggins
Endothelin in the Eye, N.N. Osborne
Ligand Structure and Activity Relationships
Conformational Studies of Endothelins and Analogs, J.T. Pelton
Endothelin Agonists, J.T. Pelton
Development of Endothelin Agonists, A.M. Doherty and W.C. Patt
Clinical Studies
Clinical Pharmacology and Pathophysiology of the Endothelins, W.G. Haynes and D.J. Webb

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