A balanced view of the causes and the prevention of the iodine defi-ciency disorders is presented in this comprehensive text. The mechanisms of goitrogenesis are explained, along with preven-tive and control measures. Descriptions of environmental com-pounds and other ecological as well as host factors involved in this process are highlighted. Public health and economic impact of the problems and treatment of individual cases are discussed.
Overview sections include:
ENVIRONMENTAL GOITROGENESIS. General Concepts of Environmental Goitrogenesis. SULFURATED OR-GANICS. Antithyroid Sulfurated Compounds. FLAVONOIDS. Physi-cal and Conformational Properties of Flavonoids. Pharmacokinetics and Intrathyroidal Effects of Flavonoids. Structure-Activity Rela-tionships of Flavonoids as Inhibitors of Iodothyronine Deiodinase. POLYHYDROXYPHENOLS AND PHENOL DERIVATIVES. Polyhy-droxyphenols and Phenol Derivatives. HYDROXYPYRIDINES. Hy-droxypyridines. PHTHALATE ESTERS AND PHTHALIC ACID DERIVATIVES. Phthalate Esters and Phthalic Acid Derivatives. POLYHALOGENATED AND POLYCYCLIC AROMATIC HYDRO-CARBONS. Polyhalogenated and Polycyclic Aromatic Hydrocar-bons. INORGANICS. Iodine Deficiency and Excess as Environmen-tal Goitrogens. Lithium Effects on the Thyroid Gland. EPIDEMIOLOGICAL ASPECTS OF ENVIRONMENTAL GOITRO-GENESIS. Epidemiological Aspects of Environmental Goitrogene-sis. GOITER ENDEMIAS ATTRIBUTED TO GOITROGENS IN FOODSTUFFS. Cassava and the Thyroid. Millet and the Thyroid. GOITER ENDEMIAS ATTRIBUTED TO CHEMICAL AND BACTERIAL POLLUTION OF WATER SUPPLIES. Goiter Endemias Attributed to Chemical and Bacterial Pollution of Water Supplies. Closing Re-marks. Index.