This work presents the proceedings of a conference held at Adare Manor, County Limerick, Ireland. It provides an updated, in-depth review of the biological role of eosinophils in allergic diseases, summarizing basic knowledge of these unique cationic proteins. The book features an annotated discussion of the conference's post-presentation question-and-answer session.
Table of Contents
"Eosinophil Granule Proteins: Structure and Function, Gerald J. Gleich, Dohn G. Glitz, and Randa I. Abu-Ghazaleh Human Eosinophil Lysophospholipase (Charcot-Leyden Crystal Protein): Molecular Cloning, Expression, and Potential Functions in Asthma, Steven J. Ackerman, Mike A. Clark, Zeqi Zhou, Charles G. Irvin, Daniel G. Tenen, and Yuan-Po Tu G-Protein Regulation of Eosinophil Exocytosis, Oliver Cromwell, Bastien D. Gomperts, and Manfred Lindau Regulation of Eosinophil Function by P-Selectin, Mathew A. Vadas, C. M. Lucas, J. R. Gambel, Angel F. Lopez, M. P. Skinner, and M. C. Berndt Structural Basis for the GM-CSF- and IL-3-Mediated Stimulation of Eosinophil Production and Function in Humans, Angel F. Lopez, J. Woodcock, T. Hercus, S. Barry, P. Dyson, P. Simmons, M. F. Shannon, and Mathew A. Vadas The Role of Adhesion Molecules and Cytokines in Eosinophil Recruitment, Robert P. Schleimer, Motohiro Ebisawa, Steve N. Georas, and Bruce S. Bochner The Role of Adhesion in Eosinophil Accumulation and Activation in Asthma, Andrew J. Wardlaw, Garry M. Walsh, A. R. E. Anwar, Adele Hartnell, Andrew M. Bentley, and A. Barry Kay Eosinophil-Active Cytokines in Human Disease: Development and Use of Monoclonal Antibodies to IL-3, IL-5, and GM-CSF, John S. Abrams, Gerald J. Gleich, Robert E. Van Dyke, and Jon E. Silver Ultrastructural Studies on Mechanisms of Human Eosinophil Activation and Secretion, Ann M. Dvorak Eosinophil Differentiation and Cytokine Networks in Allergic Inflammation, Judah A. Denburg, Jerry Dolovich, Jean Marshall, Isabelle Pin, Peter Gibson, Isao Ohno, Susetta Finotto, Fred Hargreave, and Manel Jordana Eosinophil Membrane Receptors: Function of IgE- and IgA-Binding Molecules, Monique Capron, Marie-JosE Truong, Pierre Desreumaux, BouchaIb Lamkhioued, Margherita Tomassini, and AndrE Capron Cytokine Regulation of Eosinophil-Mediated Inflammatory Reactions by Modulation of Eosinophil Programmed Cell Death and Subsequent Priming for Augmented Function, William F. O
Gerald J. Gleich Mayo Clinic and Mayo Foundation Rochester, Minnesota, A. BarryKay National Heart and Lung Institute London, England