Epigenetics, Environment, and Genes  book cover
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Epigenetics, Environment, and Genes




ISBN 9781926895253
Published April 16, 2013 by Apple Academic Press
336 Pages 50 B/W Illustrations

 
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Book Description

This title includes a number of Open Access chapters.

Epigenetics refers to DNA and chromatin modifications that play an important role in the regulation of various genomic functions. This important book reviews human and cellular data that underline paradoxical findings with respect to the contribution of heredity and environment to phenotype. The contributors then reinterpret these experiments that incorporate epigenetic factors. Topics include DNA methylation, histone modifications, chromatin modifications, the role of epigenetic modifications and environment on gene expression, and integrating genomic medicine into clinical practice.

Table of Contents

Preface
From Gene to Epigenomes
Correlating CpG Islands, Motifs, and Sequence Variants: Correlating Cpg Islands, Motifs, and Sequence Variants in Human Chromosome

DNA Methylation
Promoter Hypermethylation: Regulation of the Stem Cell Marker Cd133 Is Independent of Promoter Hypermethylation in Human Epithelial Differentiation and Cancer
Genome-Wide Mapping: Genome-Wide Mapping of Imprinted Differentially Methylated Regions by Dna Methylation Profiling of Human Placentas From Triploidies

Histone Modifications
Histone (H1) Phosphorylation: Histone H1 Interphase Phosphorylation Becomes Largely Established in G1 or Early S Phase and Differs in G1 Between T-Lymphoblastoid Cells and Normal T Cells
Post-Translational Modifications: Quantitative Analysis of Histone Exchange For Transcriptionally Active Chromatin

Chromatin Modifications
Generation of Bivalent Chromatin Domains During Cell Fate Decisions

The Role of Epigenetic Modifications and Environment on Gene Expression
Renal Kallikrein Excretion: Renal Kallikrein Excretion and Epigenetics in Human Acute Kidney Injury: Expression, Mechanisms and Consequences
Cox-2 Gene Expression: Cox-2 Gene Expression in Colon Cancer Tissue Related to Regulating Factors and Promoter Methylation Status
A Combination of Transcriptome and Methylation Analyses: A Combination of Transcriptome and Methylation Analyses Reveals Embryologically Relevant Candidate Genes in Mrkh Patients

Integrating Genomic Medicine Into the Clinical Practice
Genome Wide Association Study: Genome Wide Association Study to Predict Severe Asthma Exacerbations in Children Using Random Forests Classifiers
Epigenomics of Human Embryonic Stem Cells: Epigenomics of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells: Insights Into Pluripotency and Implications For Disease
Inhibitor of Aromatase Promoter: Potential Utility of Natural Products as Regulators of Breast Cancer-Associated Aromatase Promoters

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Editor(s)

Biography

Sun Woo Kang, MD, PhD, is Assistant Professor in the Division of Nephrology of the Department of Internal Medicine a the College of Medicine at Inje University, Korea. Dr. Kang earned his PhD and MD degrees at the Kyung Hee University Medical School in Seoul, Korea. He received a National Kidney Foundation Fellowship at the University of California at San Diego (Division of Nephrology, Department of Medicine) in 2009–2010. He has received several research grants and has several years of clinical trial experience. He is also a published author and presenter at professional meetings.