Epigenetics and Pathology : Exploring Connections Between Genetic Mechanisms and Disease Expression book cover
1st Edition

Epigenetics and Pathology
Exploring Connections Between Genetic Mechanisms and Disease Expression

ISBN 9781774633052
Published March 31, 2021 by Apple Academic Press
424 Pages 49 B/W Illustrations

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Book Description

This title includes a number of Open Access chapters.

This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including:

  • host-pathogen interactions

  • causal relationships between genes and the environment

  • the effects of environmental chemicals on gene expression

  • DNA methylation

The book also covers the analysis and provides models for understanding the epigenetics-pathology connection.

This book is designed for use by senior undergraduate and graduate students from several disciplines such as general, molecular, cellular biology, genetics, genomics, proteomics, and bioinformatics. It will also serve as a reference book for existing researchers and new investigators entering this rather unexplored field.

Table of Contents

The Link Between Epigenetics and Disease
The Epigenetics of Host-Pathogen Interactions, Elena Gómez-Díaz, Mireia Jordà, Miguel Angel Peinado, Ana Rivero
The Molecular Mechanisms of Epigenetic Regulation, Shahram Golbabapour, Mahmood Ameen Abdulla and Maryam Hajrezaei
Mutation Rate and DNA Methylation in the Human Genome, Junfeng Xia, Leng Han and Zhongming Zhao
Causal Relationships in Gene-Environment Interactions, Sara Geneletti, Valentina Gallo, Miquel Porta, Muin J Khoury and Paolo Vineis
Lysine Acetylation in Transcriptional Programming and Metabolism, Jigneshkumar Patel, Ravi R Pathak and Shiraz Mujtaba
Histone Deacetylases in Epigenetic Regulation, Geneviève P Delcuve, Dilshad H Khan and James R Davie
Aberrant Epigenetic Silencing and Gene Expression, Jon A. Oyer, Adrian Chu, Sukhmani Brar, and Mitchell S. Turker
RNAi Silencing in Poly (ADP-Ribose) Research, Christian Blenn, Philippe Wyrsch and Felix R. Althaus
MicroRNA Deregulation in Rhabdomyosarcoma and Neuroblastoma, Paolo Romania, Alice Bertaina , Giorgia Bracaglia , Franco Locatelli , Doriana Fruci and Rossella Rota
Epigenetic Effects of Environmental Chemicals, Sher Singh and Steven Shoei-Lung Li
DNA Sequence and Epigenome-Induced Pathologies, Richard B Meagher and Kristofer J Müssar

Analysis and Models for Understanding the Epigenetics-Pathology Connection
Next-Generation Sequencing Systems, Lin Liu, Yinhu Li, Siliang Li, Ni Hu, Yimin He, Ray Pong, Danni Lin, Lihua Lu, and Maggie Law
DNA Sequencing and Epigenomics Research, Martin Hirst and Marco A. Marra
Predictive Models of Gene Regulation, Sonja Althammer, Amadís Pagès, and Eduardo Eyras
Issues in Understanding Epigenetics and Disease, Chen-yu Liu, Arnab Maity, Xihong Lin, Robert O Wright and David C Christiani

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Kasirajan Ayyanathan received his PhD degree from the Department of Biochemistry, Indian Institute of Science, one of the premier research institutions in India. Subsequently, at Temple University School of Medicine, USA, he conducted post-doctoral research on the signal transduction by purinergic receptors, a class of G-Protein Coupled Receptors (GPCR), in erythroleukemia cancer cells. Next, he was trained as a staff scientist at the Wistar Institute, USA for almost ten years and studied transcription regulation, chromatin, and epigenetic regulatory mechanisms in cancer before becoming an Associate Professor at Florida Atlantic University (FAU). Currently he is at the Center for Molecular Biology and Biotechnology as a Research Associate Professor at FAU. He is the recipient of Chern memorial award and Howard Temin career research award.

Dr. Ayyanathan is well trained in molecular biology, cell biology, and biochemistry with main focus on studying transcription factors and gene regulation. Dr. Ayyanathan has published several research articles in peer-reviewed articles.