Epithelial Cell Interactions  book cover
1st Edition

Epithelial Cell Interactions

Edited By

Seema Khurana

ISBN 9781138559882
Published July 15, 2021 by CRC Press
300 Pages 8 Color & 42 B/W Illustrations

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Book Description

Epithelial cells are unique; they differentiate, have polarity, maintain cell-cell and cell-matrix interactions etc. Methods to isolate, culture and study epithelial cells are also different. Similarly, the signaling mechanisms regulating epithelial cells are different which includes protein targeting, vesicle trafficking, cytoskeletal protein distribution and function. This volume will describe a variety of methodologies employed for the study of epithelial cells. These methods include isolating primary cells and generate and maintain organoid cultures; culturing intestinal and renal epithelial cell lines; characterizing epithelial cell polarity and differentiation; and others.

Table of Contents

Cell Differentiation. Cell Polarity. Organoid cultures. Cell-Cell Interactions: Adheren junctions, Tight junctions, Desmosomes, gap junctions. Cell-matrix Interactions: Integrins, hemidesmosomes, extracellular matrix, cell attachment, cell spread. Tumor-Stromal interactions. Epithelial-mesenchymal-transition. Ion transporters and Ion Channels. Cytoskeletal changes in epithelial cells: trafficking, anchoring. Cell Signaling: including Cell Death Regulation.

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Seema Khurana is a Professor in the Department of Biology and Biochemistry at the University of Houston. He is the author or coauthor of dozens of peer reviewed journal articles. He also edited a volume in the Advances in Molecular and Cell Biology book series devoted to the cytoskeleton.