Experimental Colon Carcinogenesis: 1st Edition (Hardback) book cover

Experimental Colon Carcinogenesis

1st Edition

Edited by Herman Autrup, Gary M. Williams

CRC Press

320 pages

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Hardback: 9780367208332
pub: 2019-06-17
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pub: 2019-06-04
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First Published in 1983, Experimental Colon Carcinogenesis is a helpful guide through the development of cancer cells and the circumstances in which they develop. This book works best as a reference to all factors that must be considered with colorectal cancer and is useful for students of medicine or practitioners in their respective fields.

Table of Contents

1. Cancer Epidemiology. 2. Experimental Colon Carcinogens and Their Mode of Action. 3. In Vivo Induction of Colon Cancer Dose and Animal Species. 4. Metabolism of Chemical Carcinogens by Intestinal Tissue. 5. The Application of Organ Culture to the Study of Colon Carcinogenesis. 6. Carcinogenesis Studies in Human Gastrointestinal Epithelium. 7. Morphological Changes During Chemical Induction of Colon Cancer. 8. Comparative Pathology - Human Large Intestinal Cancer and Animal Models. 9. Cell Proliferation in Colon Carcinogenesis. 10. Colon Carcinogenesis: Biochemical Changes. 11. Familial Polyposis Coli: A Model for the Study of Promotion and Transformation. 12. The Role of Nonspecific Injury in Colon Carcinogenesis. 13. Regulation of Cell Kinetics and Colon Cancer. 14. The Two-Step Concept of Intestinal Carcinogenesis. 15. Dietry Fat and Colon Cancer. 16. In Vitro Effect of Bile Acids. 17. The Role of Fecal Microflora in Colon Carcinogenesis. 18. Dietry Fibers and Colon Cancer. 19. Inhibition of Colon Carcinogenesis.

About the Editors

Dr. Herman Autrup is Acting Chief, Carcinogen Macromolecular Interaction Section, Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland. Dr. Autrup received a Candidate of Science degree from the University of Copenhagen, Denmark, in 1970 and a Ph.D. from the University of Nairobi, Kenya, in 1975. Dr. Autrup is a member of the American Association for Cancer Research and the American Association of Pathologists and has received a Senior Investigator Fellowship from the Danish Cancer Society and a Yamagiwa-Yoshida Memorial International Cancer Fellowship., Dr. Autrup has published numerous research papers including reviews and has co-edited an NCI publication on in vitro carcinogenesis., His current research interest is the study of interaction of chemical carcinogens with cellular macromolecules and biological consequences of such interactions especially in the colon., Gary M. Williams M.D . is presently the Associate Director and Chief of the Division of Experimental Pathology and Toxicology, Naylor Dana Institute for Disease Prevention, Valhalla, New York, and Research Professor of Pathology at New York Medical College. He received his B.A. in 1963 from Washington and Jefferson College, Washington, Pennsylvania, and attended the University of Pittsburgh School of Medicine in 1967, where he acquired his doctorate of medicine., He is certified by the American Board of Pathology and the American Board of Toxicology., His research interest is chemical carcinogenesis with particular emphasis on the use of culture systems to study mechanisms of action. He has published over 150 papers on this subject., Dr. Williams is a member of the American Association for Cancer Research, American Association of Pathologists, Society for Experimental Biology and Medicine, International Academy of Pathology, Society of Toxicology, Environmental Mutagen Society, Genetics Society of America, and the Society of Toxicologic Pathologists. During 1971, he received a Research Training Fellowship from the International Agency for Research on Cancer. Among four previous awards, Dr. Williams was presented the Arnold J. Lehman Award in 1982 by the Society of Toxicology., D. H. Barkla , M.D ., Senior Lecturer, Department of Anatomy, Monash University, Clayton, Victoria, Australia, Stephen W. Barthold , D.V.M., Ph.D ., Associate Professor, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, Arthur W. Bull , M.S ., Research Assistant, Department of Surgery, Wayne State University School of Medicine, Detroit, Michigan, Emerich S. Fiala , Ph.D ., Associate Chief, Division of Molecular Biology and Pharmacology, American Health Foundation, Naylor Dana Institute for Disease Prevention, Valhalla, New York, Hugh James Freeman , M.D ., Associate Professor, Head, Division of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada, Roland Grafström , Ph.D ., Visiting Fellow, Laboratory of Experimental Pathology, National Cancer Institute, Bethesda, Maryland, Maryce M. Jacobs , Ph.D ., Associate Professor, Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska, Ole Møller Jensen , M.D., Dr. Med ., Director, Danish Cancer Registry, Copenhagen, Denmark, Morris I. Kelsey , Ph.D ., Office of Environmental Cancer, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, Martin Lipkin , M.D ., Professor and Attending Physician, Memorial Sloan Kettering Cancer Center, New York, N.Y., Young S. Kim , M.D ., Professor, Department of Medicine, University of California, Director, Gastrointestinal Research Laboratory, VA Medical Center, San Francisco, California, Laurence J. Mcintyre , Ph.D ., Assistant Research Biochemist, Department of Medicine, University of California, San Francisco, California, Norman D. Nigro , M.D ., Professor, Department of Surgery, Wayne State University School of Medicine, Detroit, Michigan, Suraiya Rasheed , Ph.D ., Professor, Department of Pathology, University of Southern California School of Medicine, Los Angeles, California, Bandaru S. Reddy , D.V.M., Ph.D ., Associate Chief, American Health Foundation, Naylor Dana Institute for Disease Prevention, Valhalla, New York, Betti Reiss , Ph.D ., Associate, Department of Experimental Pathology and Toxicology, Naylor Dana Institute for Disease Prevention, Valhalla, New York, A. K. M. Shamsuddin , M.D., Ph.D ., Assistant Professor of Pathology, University of Maryland School of Medicine, Senior Scientist, Laboratory of Experimental Pathology, National Cancer Institute, Bethesda, Maryland, C. A. Teague , M.B., Ch.B., Ph.D ., Senior Lecturer, Department of Pathology, Wellington Clinical School of Medicine, University of Otago, Wellington, New Zealand, N. Telang , Ph.D ., Research Associate, Memorial Sloan Kettering Cancer Center, Laboratory of Molecular Virology, New York, N.Y., M. H. Thompson , Ph.D ., Deputy Director, Bacterial Metabolism Research Laboratory, P.H.L.S. Centre for Applied Microbiology and Research, Salisbury, England, Peter J. M. Tutton , M.D., Ph.D ., Reader, Department of Anatomy, Monash University, Victoria, Australia, John H. Weisburger , Ph.D ., Vice President for Research, American Health Foundation, Director, Naylor Dana Institute for Disease Prevention, Valhalla, New York

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / General
MEDICAL / Oncology
MEDICAL / Pathology