During the last two decades substantial advances have been made in research on footrot and foot abscess. The results of this research are presented in this volume. Footrot and foot abscess differ from most other communicable diseases in that they are mixed bacterial infections, which are regarded as the most economically important contagious disease of sheep in Australia today.
This book is aimed at practicing veterinarians, government animal health officers and research scientists who are interested in diagnosis, treatment and prevention of economically important bacterial diseases of the ruminant hoof. It covers the microbiology of two major pathogens, Bacteroides nodosus and Fusobacterium necrophorum, and the pathology, immunology and epidemiology of footrot and foot abscess. It contains up-to-date information on various strategies currently used to control these diseases in sheep in Australia and New Zealand. Of special interest to clinicians will be sections on diagnosis which are comprehensively illustrated with pictures of various clinical entities together with differential diagnosis of other infections that localize in the digits. Developments in immunological control recently advanced by exciting opportunities to produce defined vaccines by recombinant DNA technology are also reviewed. Consideration is given to the application of biotechnology to rapid and accurate diagnosis.
THE DISEASES. Footrot of Sheep. Footrot of Cattle, Goats, and Deer. Foot Abscess of Sheep. Foot Abscess of Cattle. BACTERIOLOGY OF THE MAJOR PATHOGENS. Isolation and Identification of Bacteroides nodosus. Isolation and Identification of Fusobacterium necrophorum. IMMUNOLOGY. Antigens of Bacteroides nodosus. Antigens of Fusobacterium necrophorum. Host Responses to Footrot and Foot Abscess. Antigenic Classification of Bacteroides nodosus. Vaccination Against Footrot and Foot Abscess. APPLIED BIOTECHNOLOGY. The Molecular Biology of the Fimbriae (Pili) of Bacteroides nodosus and the Development of a Recombinant DNA-Based Vaccine. Molecular Basis of Antigenic Variation in Pili (Fimbriae) of Bacteroides nodosus - Application to Footrot Vaccines. Application of Biotechnology to the Diagnosis of Footrot. Index.