Frontal-Subcortical Circuits in Psychiatric and Neurological Disorders  book cover
1st Edition

Frontal-Subcortical Circuits in Psychiatric and Neurological Disorders

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ISBN 9781572306233
Published March 1, 2001 by Guilford Press
448 Pages

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Book Description

Contemporary research on the links between brain, mind, and human behavior has revealed the key role of the frontal-subcortical circuits in a wide range of neuropsychiatric syndromes and disorders. This authoritative volume reviews current knowledge on the anatomy of these circuits, their connections to other brain regions, and their influences on motor, cognitive, affective, and behavioral functioning. Specific clinical problems discussed include Parkinson's disease and other movement disorders, obsessive-compulsive disorder, ADHD, schizophrenia, and addictive disorders. Featured are a wealth of informative illustrations, with 8 pages in full color.

Table of Contents

1. Introduction and Overview, David G. Lichter and Jeffrey L. Cummings
2. A Revised Neuroanatomy of Frontal-Subcortical Circuits, Frank A. Middleton and Peter L. Strick
3. Neurochemistry of Frontal-Subcortical Circuits, Yuri L. Bronstein and Jeffrey L. Cummings
4. Neurophysiology of Frontal-Subcortical Loops, James C. Houk
5. Cognitive Abilities Mediated by Frontal-Subcortical Circuits, David P. Salmon, William P. Heindel, and Joanne M. Hamilton
6. Personality and Behavioral Changes with Frontal-Subcortical Dysfunction, Irene Litvan
7. The Disinhibition Syndrome and Frontal-Subcortical Circuits, Sergio E. Starkstein and Janus Kremer
8. Depression and Frontal-Subcortical Circuits: Focus on Prefrontal-Limbic Interactions, Helen Mayberg
9. Cortical-Subcortical Systems in the Mediation of Obsessive-Compulsive Disorder: Modeling the Brain's Mediation of a Classic Neurosis, Lewis R. Baxter Jr., Edward C. Clark, Mohammed Iqbal, and Robert F. Ackermann
10. Addictions and Frontal-Subcortical Circuits, Horacio A. Capote, Leayn Flaherty, and David G. Lichter
11. Movement Disorders and Frontal-Subcortical Circuits, David G. Lichter
12. Frontal-Subcortical Circuits: A Functional Developmental Approach, Marcia J. Slattery, Majorie A. Garvey, and Susan E. Swedo
13. Attention-Deficit/Hyperactivity Disorder as a Frontal/Subcortical Disorder, Kytja K. S. Voeller
14. The Role of Frontal-Subcortical Circuits in the Pathophysiology of Schizophrenia, Anthony R. West and Anthony A. Grace
15. Neuropharmacology of Frontal-Subcortical Circuits, Yuri L. Bronstein and Jeffrey L. Cummings
16. Psychosurgery of Frontal-Subcortical Circuits, Seth M. Weingarten and Jeffrey L. Cummings

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David G. Lichter, M.D. , ChB, FRACP, Dept. of Neurology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo.

Jeffrey L. Cummings, M.D., Depts. of Neurology and of Psychiatry and Biobehavioral Sciences, School of Medicine, University of California, Los Angeles.


This elegant text addresses what is perhaps the most important conceptual development in late 20th-century neuropsychiatry. There is now common agreement that brain-behavior relationships are predictably tied to the organization of discrete yet interconnected neural circuits that link the frontal and limbic cortices with the basal ganglia. This volume explores the role of these 'loops' in the primary manifestations of specific lesion-based neurologic syndromes and then, by extension, in the expression of virtually every major class of neuropsychiatric disorder. Specific dysfunction of intricate neurochemical and synaptic subterritories within the frontal-subcortical circuits must account for conditions as categorically distinct as depression, schizophrenia, OCD, substance abuse, ADHD, mania, and Tourette syndrome. Extrapolating from the signature syndromes of frontal-subcortical circuit dysfunction to the complexities of such neuropsychiatric states will require a much finer parsing of these circuits. This text can serve as a valuable primer for this process--a road map to the circuit 'interstates' as we move ahead to explore the neuronal side streets of the psyche. --Neal R. Swerdlow, MD, PhD, Department of Psychiatry, School of Medicine, University of California, San Diego

The arrival of this landmark volume could not be more timely. There is no other text available that devotes itself completely to the topic. Contributors cogently argue that a spectrum of neurological and psychiatric disorders should be placed within the context of a systems-level dysfunction. Lichter and Cummings have done a wonderful job of recruiting the leading proponents of the systems approach, and have masterfully integrated the chapters to reduce redundancy and enhance the integration of topics. This book is recommended for researchers in neuropsychiatry, behavioral neurology, and cognitive neuroscience, as well as practitioners in the clinical neurosciences who are yearning for a focused and intelligent alternative to simple localizationist views of behavior.--Jordan Grafman, PhD, Chief, Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke